To explore the effects of Shengmai Powder combined with Zhigancao Decoction on mycoplasma pneumonia with myocardial injury in children.Methods:A total of 80 children with mycoplasma pneumonia and myocardial injury admitted to Dezhou Hospital of Traditional Chinese Medicine of Shandong Province,East Hospital,from November 2016 to November 2018 were randomly divided into a control group and a study group,with 40 cases each group.The control group was treated with conventional Western medicine,and the study group was treated with Shengmai Powder combined with Zhigancao Decoction on the basis of the control group.Both groups were treated for 1 week.Before and after treatment,myocardial enzyme spectrum,symptom score and inflammation index were observed and compared between the parallel groups.The time of clinical symptom disappearance and hospitalization were collected and compared between the parallel groups.Results:The study group had more advantages than the control group in the improvement of TCM syndrome score,myocardial enzyme spectrum index improvement and inflammation index improvement,and the improvement time of clinical symptoms in the study group was shorter than that in the control group,while the total effective rate of clinical treatment was significantly higher than that in the control group,and the differences between the groups were statistically significant ( P<0.05).Conclusion:Shengmai Powder combined with Zhigancao Decoction can improve children with mycoplasma pneumonia and myocardial injury function,inhibit inflammation,shorten the symptom time,and improve the curative effects.