To systematically evaluate the efficacy and safety of Chinese herbal Compound Formula with soften hardness and dissipate masses efficacy in the treatment of thyroid nodules.Methods:RCTs of Chinese herbal compound formula with soften hardness and dissipate masses efficacy in the treatment of thyroid nodules were retrieved，methodological quality were evaluated and data was extracted，Revman5.3 software was used for Meta analysis.Results:A total of 34 clinical randomized controlled trials were included.The analysis results showed that there were statistically significant differences in the total effective rate and the reduction of the diameter of thyroid nodules between the Chinese medicine+western medicine group vs western medicine group，and between the Chinese medicine group vs western medicine group.Conclusion:Traditional Chinese medicine is more effective than western medicine in the treatment of thyroid nodules，with fewer adverse reactions and relatively safe.