| 引用本文:张素芳1,2，吕祥1.中医药对非小细胞肺癌根治术后患者免疫功能的影响[J].世界中医药,2020,(16):. |
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| 中医药对非小细胞肺癌根治术后患者免疫功能的影响 |
| Effects of Traditional Chinese Medicine on the Immune Function of the Patients in Non-small Cell Lung Cancer after Radical Resection |
| 投稿时间：2020-06-12 |
| DOI：10.3969/j.issn.1673-7202.2020.16.011 |
| 中文关键词: 中医药 非小细胞肺癌 根治术后 细胞免疫 体液免疫 回顾性队列研究 |
| English Keywords:Traditional Chinese medicine Non-small cell lung cancer Radical resection Cellular immunity Humoral immunity Retrospective cohort study |
| 基金项目:国家自然科学基金面上项目（81473627,81673947,81973795）；上海市卫健委综合医院中西医结合专项（ZHYY-ZXYJHZX-201909）；上海市科委中医引导项目（1740193350） |
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| 中文摘要: |
| 目的：通过回顾性队列研究，比较中医药治疗与术后辅助治疗或临床随访对非小细胞肺癌（NSCLC）根治术后患者细胞免疫和体液免疫功能的影响。方法：选取2016年1月至2019年12月同济大学附属上海市肺科医院收治的NSCLC根治术后患者190例作为研究对象，分为观察组（n=96）和对照组（n=94）。观察组纳入96例NSCLC根治术后进行中医药治疗并且连续服用时间大于等于6个月患者，对照组纳入94例术后辅助治疗或临床观察随访患者，比较2组组间及治疗前后外周血T淋巴细胞亚群、NK细胞、免疫球蛋白及补体水平的变化。结果：组间比较发现观察组NK和CD3+水平较对照组上调（P<0.05），IgM含量较对照组显著升高（P<0.01）。组内比较发现观察组能显著上调NK和CD3+的水平和IgM的含量（P<0.01），能明显上调血C3和C4含量（P<0.05）。结论：中医药治疗能提高NSCLC根治术后患者的细胞免疫和体液免疫功能，可能是其延长术后总生存期、减少复发和转移的机制。 |
| English Summary: |
| Through a retrospective cohort study，the effects of traditional Chinese medicine(TCM)treatment，postoperative adjuvant therapy or clinical follow-up on the cellular and humoral immunity of patients after non-small-cell lung cancer(NSCLC)radical surgery were compared.Methods:A total of 190 patients who underwent radical surgery for NSCLC from January 2016 to December 2019 in the inpatient department or outpatient department of Shanghai Pulmonary Hospital affiliated to Tongji University were selected as the research objects.The observation group included 96 patients who underwent TCM treatment after NSCLC radical resection and had been taking TCM treatment continuously for 6 months or more.The control group included 94 patients who received postoperative adjuvant therapy or clinical observation follow-up.The levels of T lymphocyte subsets，NK cells，immunoglobulin and complement in peripheral blood were compared between the 2 groups before treatment and after treatment.Results:The comparison between groups showed that the NK and CD3+ levels in the observation group were significantly up-regulated compared with the control group(P<0.05)，and the IgM content was significantly increased compared with the control group(P<0.01).After comparison within groups，it was found that the NK，CD3+ and IgM levels were significantly up-regulated in the observation group(P<0.01)，and the levels of C3 and C4 were up-regulated(P<0.05).Conclusion:TCM can improve the cellular and humoral immunity of patients，which may be the mechanism to prolong the overall postoperative survival of NSCLC after radical surgery and reduce the recurrence and metastasis. |
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