To investigate the effects of Yinzhihuang Oral Liquid combined with Saccharomyces boulardii on bilirubin level and nervous system in neonates with hyperbilirubinemia.Methods:A total of 60 neonates with hyperbilirubinemia admitted to Wanbei Coal and Electricity Group General Hospital from January 2018 to January 2019 were selected and divided into a control group(n＝30)and an observation group(n＝30)according to random number table method.The child patients in the control group were treated with blue light irradiation，and those in the observation group was given Yinzhihuang Oral Solution(1/3 each time，3 times/d)combined with Saccharomyces boulardii(0.25 g/time，2 times/d)oral treatment.Both groups were treated continuously for 6 d.The clinical efficacy of the 2 groups were compared after treatment; the levels of transcutaneous bilirubin(TcB)before and after 36，72，108 and 144 h of treatment were detected and compared; the neurological abnormalities before and after treatment in 2 groups ［including brainstem auditory evoked potential(BAEP)，amplitude-integrated electroencephalogram(aEEG)and magnetic resonance imaging(MRI)］ were compared; the incidence of adverse reactions in the 2 groups were compared.Results:The total clinical effective rate of the observation group(93.33%)was significantly higher than that of the control group(66.67%)(P<0.05); Compared with those before treatment，36，72，108，and 144 h after treatment，the TcB levels of the 2 groups decreased significantly，and gradually decreased over time，and the observation group was lower than the control group; compared with those before treatment，the abnormal rates of BAEP，aEEG and MRI examinations of the 2 groups significantly reduced after treatment，and the observation group was significantly lower than the control group(P<0.05); compared with that of the control group(16.67%)，the total incidence of adverse reactions(30.00%)in the observation group was not statistically significant(P>0.05).Conclusion:Yinzhihuang Oral Liquid combined with Saccharomyces boulardii has a significant effects on neonatal hyperbilirubinemia，which can significantly reduce TcB levels and improve the nervous system damage in child patients，and it was conducive to prognosis and has good safety，which is worthy of clinical application.