Autism is a developmental disorder that occurs in early childhood.At present，Western medicine's understanding of the cause of this disease is still unclear，but many hypotheses have been put forward.In recent years，the theory of intestinal flora as the cause has become more popular.It is believed that it is closely related to the brain-gut axis and has no specific therapeutic drugs.There is no clear record of the name of “Autism” in ancient Chinese medicine history books，but there is no lack of explanations of the etiology，pathogenesis and core symptoms of the disease.The paper focuses on the spleen-kidney-brain communication theory and the correlation with the intestinal flora，in order to explores the thinking of TCM treatment for Autism.