To analyze the predictive factors of the differential diagnosis between diabetic kidney disease (DKD) and non-diabetic kidney disease (NDKD),summarize the usage of Chinese patent medicine in type 2 diabetic mellitus(T2DM)complicated with chronic kidney disease(CKD) patient, to provide a reference for identification of NDKD and rational usage of Chinese patent medicine.Methods:A retrospective study was conducted to observe 463 type 2 diabetic patients who underwent renal biopsy in China-Japan Friendship Hospital from 2010 to 2018.The patients were divided into3 groups, 65 in DKD group (14.04%),85 in DKD complicated with NDKD group (18.36%),and 313 in NDKD group (67.60%) according to the pathological results.Logistic regression analysis was used to screen the clinical predictive factors of NDKD,and the regularity of Chinese patent medicine in the treatment of type 2 diabetes mellitus complicated with chronic kidney disease were summarized.Results:1）The clinical predictors of T2DM NDKD include:non-diabetic retinopathy, course of diabetes<6 years,hemoglobin ≥ 120 g / L, glomerular hematuria, proteinuria without meeting the standard of nephropathy syndrome.Non-diabetic retinopathy had the highest predictive significance (OR,14.902; 95% CI,5.989-37.07);2）Huangkui capsule was the most commonly used Chinese patent medicine for treatment of T2DM complicated with CKD,followed by Cordyceps, Haikun Shenxi capsule and Niaodu Qing granules.Single use of Chinese patent medicine in NDKD group was higher while combination of four or more Chinese patent medicine ratio was lower than the other two groups (P<0.001).With the development of CKD,the proportion of Huangkui capsule decreased,the proportion of Niaodu Qing granules increased,the proportion of Cordyceps and haikun Shenxi capsule in CKD3-4 stage was higher,and it decreased in CKD5 stage. Conclusion:1）The clinical predictors of NDKD include mainly non-diabetic retinopathy,besides, course of diabetes<6 years,hemoglobin ≥ 120 g / L, glomerular hematuria and so on also have significance.2）Chinese patent medicine is widely used in chronic kidney disease.The most commonly used drugs for proteinuria are Huangkui capsule, with the development of disease, the useage propotion of Cordyceps, haikun Shenxi capsule and Niaodu Qing granules were changed.