To explore the composition,target,activity and pathway of ‘Salviae Miltiorrhizae Radix Et Rhizoma and Puerariae Lobatae Radix’ in the treatment of ischemic stroke and to provide scientific evidence for molecular mechanism of Traditional Chinese medicine drug pair.Methods:This paper analyzed the active ingredients,action targets and pathways based on network pharmacology platform.Results:A total of 16 crucial ingredients and 28 core targets and 30 related pathways were predicted in the study,and active compositions of the drug pair were miltipolone,sugiol,ferruginol,oleanolic acid,eleutheroside A,succinic acid,ursolic acid,baicalin,arachidic acid,salviol,Carrot (sterol) glycoside,kudzusapogenol B methyl ester,daidzein,genistein,Formononetin,Kaikasaponin Ⅲ etc; the core target were mainly concentrated in COX family,ATP family,PTGS2 etc; main pathways are chemokine signaling pathway,toll-like receptor signaling pathway,oxidative phosphorylation,cGMP-pkg signaling pathway,etc.It showed that ‘Salviae Miltiorrhizae Radix Et Rhizoma and Puerariae Lobatae Radix’ in the treatment of ischemic stroke may be related to antioxidant,anti-inflammatory protection.Conclusion:The components of ‘salviae miltiorrhizae radix et rhizoma and puerariae lobatae radix’can treat ischemic stroke by inhibiting inflammatory and anti-oxygen free radical.