| 引用本文:杨长花1，卫昊2，刘峰1,3，许刚1,3，张彦民1，王月茹1.基于网络药理学探讨“丹参-葛根”药对治疗缺血性脑卒中的机制[J].世界中医药,2020,(17):. |
|
| 基于网络药理学探讨“丹参-葛根”药对治疗缺血性脑卒中的机制 |
| Exploration on the Mechanism of ‘Salviae Miltiorrhizae Radix Et Rhizoma and Puerariae Lobatae Radix’Drug Pair for Ischemic Stroke Treatment Based on Network Pharmacology |
| 投稿时间：2019-03-01 |
| DOI：10.3969/j.issn.1673-7202.2020.17.006 |
| 中文关键词: 整合药理学 丹参 葛根 药对 缺血性脑卒中 脑卒中 分子药理 配伍 |
| English Keywords:Network pharmacology Salviae Miltiorrhizae Radix Et Rhizoma Puerariae Lobatae Radix Drug pair Ischemic stroke stroke Molecular pharmacology Compatibility |
| 基金项目:社会发展科技攻关项目（2016SF-389）；中药绿色制造技术协同创新中心项目(陕教[2018]12号)；生物医药创新制药技术研究院士专家工作站项目（陕科协发[2017]事企字15号）；陕西省中药制药关键性技术重点研究室项目（陕中医药发[2016]29号） |
|
| 摘要点击次数: 453 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨“丹参-葛根”药对治疗缺血性脑卒中的成分、靶点、活性、通路，为探讨中药药对的分子作用机制提供科学依据。方法：通过网络药理学平台，分析“丹参-葛根”药对的活性成分、作用靶点及通路，探讨中药药对的分子作用机制。结果：预测到关键成分16个，相关核心靶标28个，相关通路30个，药对发挥作用的成分有丹参环庚三烯酚酮、柳杉酚、弥罗松酚、齐墩果酸、刺五加苷A、琥珀酸、熊果酸、黄芩苷、花生油酸、鼠尾草酚、胡萝卜(甾醇)苷、葛根皂醇B甲酯、大豆素、染料木素、刺芒柄花素、槐花皂苷Ⅲ等；核心靶标主要集中在COX family，ATP family，PTGS2等，涉及的主要通路有趋化因子信号通路、Toll受体信号通路、氧化磷酸化、cGmp-pkg信号通路等,显示“丹参-葛根”治疗缺血性脑卒中可能与抗氧化、抗炎保护等有关。讨论：“丹参-葛根”所含成分可能通过抑制炎性反应、抗氧自由基等来治疗缺血性脑卒中。 |
| English Summary: |
| To explore the composition,target,activity and pathway of ‘Salviae Miltiorrhizae Radix Et Rhizoma and Puerariae Lobatae Radix’ in the treatment of ischemic stroke and to provide scientific evidence for molecular mechanism of Traditional Chinese medicine drug pair.Methods:This paper analyzed the active ingredients,action targets and pathways based on network pharmacology platform.Results:A total of 16 crucial ingredients and 28 core targets and 30 related pathways were predicted in the study,and active compositions of the drug pair were miltipolone,sugiol,ferruginol,oleanolic acid,eleutheroside A,succinic acid,ursolic acid,baicalin,arachidic acid,salviol,Carrot (sterol) glycoside,kudzusapogenol B methyl ester,daidzein,genistein,Formononetin,Kaikasaponin Ⅲ etc; the core target were mainly concentrated in COX family,ATP family,PTGS2 etc; main pathways are chemokine signaling pathway,toll-like receptor signaling pathway,oxidative phosphorylation,cGMP-pkg signaling pathway,etc.It showed that ‘Salviae Miltiorrhizae Radix Et Rhizoma and Puerariae Lobatae Radix’ in the treatment of ischemic stroke may be related to antioxidant,anti-inflammatory protection.Conclusion:The components of ‘salviae miltiorrhizae radix et rhizoma and puerariae lobatae radix’can treat ischemic stroke by inhibiting inflammatory and anti-oxygen free radical. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
