To study the medication rules of professor WANG Yaoxian for chronic renal failure(CRF)based on the theory of miniature mass of renal collateral and to summarize the academic experience.Methods:A total of 270 first prescription by Prof.WANG Yaoxian for treating chronic renal failure were collected.The association rules，complex entropy clustering and other methods were used to analyze the medication rules and the characteristics of the prescriptions.Results:1)A total of 270 prescriptions were included，involving 184 drugs; 2)Through association rule mining，the support was set to“81”and the confidence was“0.8”.A total of 114 commonly used drug combinations were obtained.3)Choose a correlation coefficient of 8 and a penalty coefficient of 2.Through unsupervised entropy hierarchical clustering algorithm，through evolution and further clustering，10 new prescriptions are obtained.4)In terms of four qi，cold medicine，warm medicine and calm medicine are most used，and heat medicine is the least.5)In terms of the five flavors are concerned，those who use sweetness are the most frequently used，followed by bitter，bitter，salty，and sour，and those with astringent least.6)In terms of menstruation，the hepatic meridian is the most，followed by the spleen meridian and the kidney meridian，followed by the stomach，lung，heart，gallbladder，large intestine，small intestine，bladder，pericardium，and Sanjiao etc.Conclusion:The data mining method is used to objectively summarize the characteristics of Professor Wang Yaoxian's treatment of diversified and individualized medication with“miniature mass of renal collateral”as the core.