Abstract:To observe the effect of Xuefu Zhuyu decoction and Wendan decoction combined with Western medicine in the treatment of hypertensive carotid atherosclerosis.Methods:A total of 92 patients with hypertensive carotid atherosclerosis admitted to Liaocheng traditional Chinese Medicine Hospital from June 2017 to June 2018 were collected, and were randomly divided into control group and observation group according to the random number table method, with 46 cases in each group. Patients in the control group were given Levamlodipine+atorvastatin orally, and the observation group was added with Xuefu Zhuyu decoction and Wendan decoction on the basis of the control group. The patient's blood pressure and blood lipid control were observed, and the carotid artery intima-media thickness (IMT), plaque area, vascular endothelial function, and serum protease molecular level were detected.Results:Compared with the control group, the observation group had lower blood pressure SBP, DBP and blood lipids TG, TC, LDL-C and other indicators after treatment (P<0.05); carotid atherosclerotic plaque IMT and plaque area were significantly reduced (P<0.05), the levels of vascular endothelial function indexes ET-1, AngⅡ, and TXB2 were significantly reduced, and the level of NO was significantly increased (P<0.05); the levels of serum CatK and MMP-9 were significantly reduced (P<0.05); the adverse reactions in the observation group(8.70% ) was significantly lower than the control group (21.74%)(P<0.05).Conclusion:Xuefu Zhuyu decoction and Wendan decoction combined with Western medicine is more beneficial to the control of blood pressure in patients with hypertensive carotid atherosclerosis,the regulation of lipid metabolism,the improvement of vascular endothelial function,the reduction of serum protease molecule content,and the safety of drug use.