世界中医药

目的：通过网络药理学方法探讨加味过敏煎治疗荨麻疹的作用机制。方法：检索中药系统药理学平台(TCMSP)选取加味过敏煎君药中的有效元素和作用靶点；通过检索人类基因信息数据库选取荨麻疹的疾病靶点；应用R语言筛选药物与疾病共同靶点，应用Cytoscape软件构建药物-化合物-作用靶点-疾病互作网络；运用STRING平台构建蛋白质间相互作用网络（PPI），并将结果进行可视化展示；使用Bioconductor生物信息软件包进行GO功能富集分析和KEGG通路分析。结果：包含了45个化合物和相应靶点409个，并得到61个疾病相关作用靶点。富集分析得到84个GO功能条目和126条KEGG信号通路。结论：加味过敏煎作用于荨麻疹的PPI网络中IL-6、AKT1、VEGFA等靶点起着关键作用，这些靶点主要涉及细胞因子受体结合、细胞因子及受体配体活性等生物学过程，并主要富集在AGE-RAGE、PI3K/Akt等多条信号通路上，发挥抗炎和免疫调节等作用，这可能是加味过敏煎治疗荨麻疹的关键作用机制。

English Summary:

To explore the mechanism of modified allergic Decoction in the treatment of urticaria based on network pharmacology theory. Methods:Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) was used to select the effective constituents and action targets of Jiawei allergic Decoction. Human gene information database was used to select the disease targets of urticaria. R language software was used to screen the common targets of drugs and diseases, Cytoscape software was used to build drug-ingredient-action target-disease interaction network. Protein protein interaction network(PPI) was constructed by using the STRING platform, and the results were visualized. Bioconductor bioinformatics software package was used to perform Gene Ontology (GO) function enrichment and Kyoto pathway analysis. Results:A total of 45 compounds and 409 corresponding targets were included, and 61 disease-related targets were obtained. Enrichment analysis yielded 84 GO function entries and 126 KEGG signal pathways. Conclusion:Jiawei allergic Decoction plays a key role in IL-6, AKT1, VEGFA and other targets in the PPI network of urticaria. These targets mainly involve the biological processes of cytokine receptor binding, cytokine and receptor ligand activity, etc. It is mainly enriched in multiple signal pathways such as AGE-RAGE, PI3K/Akt, and exerts anti-inflammatory and immunomodulatory effects. This may be the key mechanism of Jiawei allergic Decoction in the treatment of urticaria.

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