| 引用本文:张易欣，张强，王菊荣，李美艳，刘平，韩新彦.养精种玉汤辅助体外受精-胚胎移植对排卵障碍性不孕患者的影响[J].世界中医药,2020,(18):. |
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| 养精种玉汤辅助体外受精-胚胎移植对排卵障碍性不孕患者的影响 |
| Effects of Yangjing Zhongyu Decoction Assisted in Vitro Fertilization-embryo Transfer on the Patients with Ovulatory Disorder Infertility |
| 投稿时间：2020-06-08 |
| DOI：10.3969/j.issn.1673-7202.2020.18.013 |
| 中文关键词: 排卵障碍性不孕 养精种玉汤 体外受精-胚胎移植 子宫内膜容受性；取卵数量；妊娠率；搏动指数；阻力指数 |
| English Keywords:Ovulatory disorder infertility Yangjing Zhongyu Decoction In vitro fertilization-embryonic transfer Endometrial tolerance Number of eggs retrieved Pregnancy rate Pulsatility index Resistance index |
| 基金项目:河北省科技计划项目（162777198）；邯郸市科学技术研究与发展计划研究项目（1823208055ZC） |
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| 中文摘要: |
| 目的：探究养精种玉汤辅助体外受精-胚胎移植（IVF-ET）对排卵障碍性不孕患者的影响。方法：选取2016年12月至2017年3月邯郸市中心医院收治的排卵障碍性不孕患者82例作为研究对象，按照随机数字表法随机分为对照组与观察组，每组41例。对照组给予促性腺激素释放激素激动剂（Gn）+控制性促排卵+IVF-ET治疗，观察组在此基础上联合养精种玉汤治疗，至HCG日停止服用。治疗后统计2组Gn使用情况、取卵数及妊娠率；检测并比较HCG日2组子宫内膜容受性指标；比较2组妊娠结局及治疗期间相关不良反应发生情况。结果：观察组Gn使用天数及使用剂量均低于对照组，而妊娠率高于对照组（P<0.05或P<0.01）；观察组子宫内膜类型为A型患者比例高于对照组，而子宫内膜类型为C型患者比例低于对照组（P<0.05或P<0.01）；观察组子宫内膜厚度大于对照组，而子宫内膜动脉血流参数PI及RI均低于对照组（P<0.01）；2组不良反应发生率差异无统计学意义（P>0.05），且治疗期间2组血清肝功能指标及血尿常规检测均未发现异常。结论：养精种玉汤辅助IVF-ET可有效增强排卵障碍性不孕患者子宫内膜容受性，提高患者妊娠率并改善其妊娠结局，具有良好的安全性。 |
| English Summary: |
| To explore the effects of Yangjing Zhongyu Decoction assisting in vitro fertilization-embryonic transfer(IVF-ET)on patients with ovulatory infertility.Methods:A total of 82 cases of ovulation barrier steile patients admitted to Handan Central Hospital from Dec.2016 to Mar.2017 were selected and randomly divided into a control group and an observation group，with 41 cases in each group.Patients in control group were treated with gonadotropin release hormone agonist(Gn)+controlled ovulation+IVF-ET，and patients in the observation group were treated with Yangjing Zhongyu Decoction on the basis of control group，and stop taking until to HCG day.The use condition of Gn，number of follicles and pregnancy rate in 2 groups were statisticsed after treatment，the endometrial tolerance indexes at HCG day in 2 groups were detected and compared; the pregnancy outcome and related adverse reactions occurrence during the treatment in 2 groups were compared.Results:The using days and using dose in observation group were lower than those in control group，while the pregnancy rate in observation group was lower than that in control group(P<0.05 or P<0.01); the proportion of patients with A type endometrium in observation group was higher than that in control group，while the proportion of patients with C type endometrium was lower than that in control group(P<0.05 or P<0.01); the endometrial thickness in observation group was greater than that in control group，while the endouterine artery blood flow parameters of PI and RI were lower than those in control group(P<0.01); there was no significant difference in the occurrence rate of adverse reactions between 2 groups(P>0.05)，and serum abnormal liver function index and routine blood and urine test had no abnormal phenomenon of patients in 2 groups during the treatment.Conclusion:Yangjing Zhongyu Decoction assisting IVF-ET can enhance the endometrial tolerance of ovulation barrier steile patients，increase the pregnancy rate and improve the pregnancy outcome，which has good security. |
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