To explore the clinical effects of acupuncture at Siguan point on Parkinson's disease.Methods:We conducted retrospective analysis on 60 PD patients admitted to Shenzhen Bao'an Traditional Chinese Medicine Hospital and randomly divided the patients into a study group(n＝30)and a control group(n＝30)according to different treatment.The control group was treated with drug therapy combined with deep brain stimulation，and the study group was treated with acupuncture at Siguan point on the basis of the control group for 8 weeks.The differences of oxidative stress，Parkinson's comprehensive scale(UPDRS score)，quality of life scale(WHO-QOL-2)，electromyographic tremor and clinical effects were compared between the 2 groups before and after treatment.Results:1)After treatment，the mental，behavioral and emotional scores，daily activity scores，motor function scores，motor complication scores，UPDRS total scores，interleukin-1 β(IL-1 β)，IL-6，malondialdehyde(MDA)，frequency and intensity of tremor in fixed position and resting tremor and in sitting position were lower than those in treatment group.Physiology，environment，independence，social relations，psychology，total score of WHO-QOL-2，superoxide dismutase(SOD)and dopamine(DA)were significantly higher than those before treatment.The observation group is better than the control group(P<0.05).2)the markedly effective rate and the total effective rate of the observation group were 46.67% and 86.67%，respectively，which were better than 30% and 73.33% of the control group，and the difference was statistically significant(P<0.05).Conclusion:Acupuncture at Siguan point can improve the condition of PD，and the mechanism may be related to the inhibition of inflammation and oxidative stress.