Using same treatment for different diseases is a common phenomenon in clinical practice of traditional Chinese Medicine (TCM). The diagnosis and treatment mode of disease and syndrome combination is its embodiment. Starting from the clinical treatment of different diseases with the same treatment, based on the curative effect, it is an important way to reveal the scientific connotation of basic syndromes by comparing horizontally and vertically observing the similarities and differences of the “prescription-syndrome” effects before and after treatment and the internal mechanism between different diseases. “Positive deficiency and blood stasis”were the pathogenesis characteristics of chronic liver, lung, and kidney diseases. There is a theoretical basis for “different diseases with the same treatment” to replenish deficiency and remove blood stasis, and there is a material basis for prescription-syndrome effects. Combination of disease and syndrome, precise treatment, and improvement of prognosis are the development trends in the treatment of organ fibrotic diseases. Therefore, based on the basic pathogenesis of liver, lung, and kidney fibrosis in TCM with the “positive deficiency and blood stasis” of TCM, the prospective RCT clinical trial of combining disease and syndrome and treating different diseases with the same treatment was carried out by loading TCM for strengthening the body and removing blood stasis.” And using clinical information and biological samples to discover the characteristics of the target population and explore the corresponding internal principles of the prescriptions and syndromes will help to clarify the connotation of the syndromes of the deficiency and blood stasis, and promote the treatment of major refractory diseases in TCM.