| 引用本文:赵志祥，简小兵，王文英.玉液汤对2型糖尿病肥胖患者肠道菌群及脂质代谢的影响[J].世界中医药,2020,(19):. |
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| 玉液汤对2型糖尿病肥胖患者肠道菌群及脂质代谢的影响 |
| Effects of Yuye Decoction on Intestinal Microflora and Lipid Metabolism in Obesity Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2019-06-28 |
| DOI：10.3969/j.issn.1673-7202.2020.19.022 |
| 中文关键词: 玉液汤 2型糖尿病 肥胖 肠道菌群 脂质代谢 中医症状积分 血糖 胰岛素抵抗 |
| English Keywords:Yuye Decoction Type 2 diabetes mellitus Obesity Intestinal flora Lipid metabolism TCM symptom score Blood sugar Insulin resistance |
| 基金项目:2018年度广东省中医药局科研项目（20181202）；2018年度广州市中医药和中西医结合科研项目（20182A011009） |
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| 中文摘要: |
| 目的：探讨玉液汤对2型糖尿病肥胖患者肠道菌群及脂质代谢影响。方法：选取2017年2月至2019年2月广州市中医医院收治的2型糖尿病肥胖患者106例作为研究对象，按照就诊顺序分为对照组和观察组，每组53例。2组均给予基础治疗+药物治疗，观察组再加用玉液汤治疗。观察2组治疗前、完成治疗后肠道菌群、脂质代谢、中医症状积分、血糖相关指标、体质量、腰围、体质量指数(BMI)变化并比较。结果：2组治疗前各指标比较差异无统计学意义（P>0.05），完成治疗后观察组患者的中医症状积分、FINS、HOMA-IR、HbAlc、BMI、腰围、体质量、TC、TG、LDL-C、肠杆菌、酵母菌、肠球菌、畏寒肢冷、腰膝酸软、脘腹2组患者治疗后HDL-C、双岐杆菌、乳杆菌、拟杆菌均较治疗后明显上升，且观察组高于对照组（P<0.05）。结论：玉液汤能改善2型糖尿病肥胖患者脂质代谢和临床症状，降低血糖，能调节肠道菌群紊乱，从而提高疗效。 |
| English Summary: |
| To explore the effects of Yuye Decoction on intestinal flora and lipid metabolism in type 2 diabetic obese patients.Methods:A total of 106 type 2 diabetic obese patients admitted to Guangzhou Chinese Medicine Hospital were divided into a control group and a study group according to diagnostic order，with 53 cases in each group.Both groups were given basic treatment+drug treatment，and the study group was treated with Yuye Decoction on the bases of the control group.Before and after treatment，intestinal flora，lipid metabolism，TCM symptom score，blood glucose related indicators，body weight，waist circumference，BMI were observed and compared between the 2 groups.Results:There was no significant difference between the 2 groups before and after treatment(P>0.05).After treatment，the symptom scores of TCM，FINS，HOMA-IR，HbAlc，BMI，waist circumference，body weight，TC，TG，LDL-C，enterobacteriaceae，yeast，enterococcus，chilly limbs，sore waist and knees，wan abdomen in the observation group were significantly higher than those after treatment.The observation group was higher than the control group(P<0.05).Conclusion:Yuye Decoction can improve lipid metabolism and clinical symptoms of type 2 diabetes mellitus，reduce blood sugar，regulate intestinal flora disorder，and improve the therapeutic effects. |
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