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文章摘要
引用本文:姬莉1，娄颜1，陈思2，王振民3，汪红兵1，李舒敏1，董礼刚1.疏肝健脾方治疗功能性胃肠病重叠综合征的临床效果[J].世界中医药,2020,(20):.  
疏肝健脾方治疗功能性胃肠病重叠综合征的临床效果
Clinical Study on the Shugan Jianpi Formula in the Treatment of Dyspepsia Overlap Syndrome
投稿时间：2018-12-20  
DOI：10.3969/j.issn.1673-7202.2020.20.016
中文关键词:  功能性胃肠病重叠综合征  疏肝健脾法  IBS病情变化积分表  大便性状问卷  疗效评价  多中心  随机  双盲  安慰剂  对照
English Keywords:Functional dyspepsia overlap syndrome disease  Soothing liver and invigorating Spleen Method  IBS condition change score table  Defection state questionnaire  Curative effect evaluation  Multi-center  Randomly  Double blind  Placebo  Control
基金项目:北京市属医院科研培育项目(PZ2016007)
作者单位
姬莉1，娄颜1，陈思2，王振民3，汪红兵1，李舒敏1，董礼刚1 1 首都医科大学附属北京中医医院，北京，100010； 2 北京中医医院顺义医院，北京，101300； 3 北京中医医院延庆医院，北京，102100 
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中文摘要:
      目的:观察疏肝健脾法治疗功能性胃肠病重叠综合征（FGIDs）的疗效，为中医药防治功能性胃肠病重叠综合征提供更有效的治疗方法。方法:采用多中心、随机、双盲、安慰剂对照研究，选取2016年6月至2018年7月首都医科大学附属北京中医医院消化中心、北京中医医院顺义医院、北京中医医院延庆医院门诊或者住院部收治的患有功能性胃肠病重叠综合征的患者108例作为研究对象，随机分为观察组（n＝53）和对照组（n＝52），分别用疏肝健脾方以及安慰剂治疗。2组治疗疗程均为4周。分别在治疗前，治疗2周，治疗4周记录患者主要西医临床症状积分、IBS病情变化积分及大便性状。结果：观察组治疗有效率为81%，对照组治疗有效率为46%，观察组疗效优于对照组差异有统计学意义（P<0.05）。观察组在上腹痛、上腹烧灼感、恶心、早饱感方面疗效，与对照组比较差异有统计学意义（P<0.05）。观察组和对照组的IBS病情变化疗效有效率分别为83%和52%，差异有统计学意义（P<0.05）。治疗后观察组在每天排便最多的次数和10 d中排便急迫感的天数两方面优于对照组，差异有统计学意义（P<0.05）。结论：疏肝健脾方治疗功能性胃肠病重叠综合征有一定的临床疗效。
English Summary:
      To observe the clinical curative effects of treating functional gastrointestinal overlap irritable bowel syndrome disease using soothing liver and invigorating spleen,providing a more effective treatment method for preventing and treating functional gastrointestinal overlap syndrome with traditional Chinese medicine(TCM).Methods:A multi-center,randomized,double-blind,placebo-controlled study was adopted,and a total of 108 patients were selected as the research objects from June 2016 to July 2018 admitted in the Digestive Center of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine,and Yanqing Hospital of Beijing Hospital of Traditional Chinese Medicine,and were randomly divided into a TCM group(n＝53)and a placebo group(n＝52).They were treated with Shugan Jianpi Decoction and placebo respectively.The treatment course of the 2 groups was 4 weeks.Before treatment,after 2 weeks of treatment and 4 weeks of treatment,the patient's main Western medicine clinical symptom score,IBS condition change score and stool characteristics were recorded.Results:1)Evaluation of the overall curative effects of Western medicine symptoms：the total effective rate of the TCM group was 81%,and the total effective rate of the placebo group was 46%.The curative effects of TCM group was better than that of the placebo group(P<0.01).2)Compared with the placebo group,the curative effects of the TCM group on upper abdominal pain,upper abdominal burning sensation,nausea,and early satiety was statistically significant(P<0.05).3)Evaluation of curative effect of changes in IBS condition：the total effective rates of the TCM group and the placebo group were 83% and 52%,respectively,and there was a significant difference between the groups(P<0.01).4)Evaluation of the curative effect of stool characteristics：after treatment,the TCM group was better than the placebo group in terms of the maximum number of bowel movements per day and the number of days of defecate urgency in 10 days(P<0.05).Conclusion:Shugan Jianpi Formula treating FD overlap IBS has good clinical curative effect.
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