To explore the effects of Guizhi Shaoyao Zhimu Decoction on laboratory indexes and immune function of patients with rheumatoid arthritis.Methods:A total of 110 patients with rheumatoid arthritis admitted to the Affiliated Chinese and Western Medicine Hospital of Nanjing,Nanjing University of Chinese Medicine from December 2014 to December 2016 were selected as the research objects and were divided into a control group and an observation group by random number table method,with 55 cases in each groups.The control group was treated with routine Western medicine,and the observation group was treated with Guizhi Shaoyao Zhimu Decoction on the basis of the control group.The 2 groups were treated for 1 month.The clinical effects,improvement of clinical symptoms,laboratory indicators and immune function indicators level between the 2 groups were compared; the incidence of adverse reactions in the 2 groups was counted.Results:The total effective rate in the observation group was 92.73%,higher than the control group (78.18%,P<0.05).Compared with that before treatment,after 1 month of treatment,the grip strength in the 2 groups increased,and the observation group was larger than the control group (P<0.05); the time of morning stiffness and 20 m walking time in the 2 groups shortened,and the observation group were shorter than the control group (P<0.05); the number of joint tenderne,joint swellin,the levels of ESR,MPV,PDW and serum CRP,plasma IgA,IgG,IgM,RF level in both groups decreased,the observation group is lower than the control group (P<0.05); the level of serum C3 in the 2 groups increased,and the observation group was higher than the control group (P<0.05).During the treatment,the incidence of adverse reactions in the observation group was 0.00%,lower than the control group (10.91%,P<0.05).Conclusion:Guizhi Shaoyao Zhimu Decoction in the treatment of rheumatoid arthritis could improve the patient's laboratory indicators,enhance immune function,improve curative effect,and has high safety.