世界中医药

目的：研究清热化湿方联合四联疗法对萎缩性胃炎伴糜烂患者的疗效及对血清胃蛋白酶原比值（PGR）及胃泌素-17（G-17）的影响。方法：选取2016年12月至2018年5月新疆医科大学附属中医医院收治的萎缩性胃炎伴糜烂患者90例作为研究对象，按随机数字表法分为观察组和对照组，每组45例。对照组予以四联疗法联合常规西医治疗，观察组施予清热化湿方联合四联疗法，比较2组疗效及PGR、G-17水平。结果：治疗后，观察组病理组织学有效率91.11%，与对照组的82.22%比较差异无统计学意义（P>0.05），而观察组中医证候有效率97.78%，比对照组的66.67%高，差异有统计学意义（P<0.05）；观察组中医症状积分（6.89±3.45）分，比对照组的（10.51±4.03）分低，差异有统计学意义（P<0.05）；观察组慢性炎性反应及萎缩评分均比对照组低，差异有统计学意义（P<0.05）；观察组PGR（6.88±2.41），与对照组的（7.24±2.36）比较，差异无统计学意义（P>0.05），而观察组G-17水平是（7.31±1.32）pmol/L，比对照组的（5.43±1.30）pmol/L高，差异有统计学意义（P<0.05）。结论：清热化湿方联合四联疗法有助于提升萎缩性胃炎伴糜烂患者疗效，并促使其症状改善。

English Summary:

To explore the effects of Qingre Huashi prescription combined with quadruple chemotherap on the patients with chronic atrophic gastritis with erosion and its influences on the PGR and G-17.Methods:A total of 90 patients with chronic atrophic gastritis with erosion patients admitted to Chinese Medicine Hospital Affiliated to Xinjiang Medical University from December 2016 to May 2018 were selected as the research object and were divided into an experimental group and a control group according to computer-generated number table method,with 45 cases in each group.The patients in the control group were treatment with quadruple chemotherap combined with routine Western medicine,and the experimental group was treatment with Qingre Huashi Prescription combined with quadruple chemotherap.The efficacy and the levels of PGR and G-17 were compared between the 2 groups.Results:After treatment,the histopathology effective rate of the experimental group was 91.11%,and there was no significant difference between the control group of 82.22%(P>0.05); while the TCM symptom effective rate of the experimental group was 97.78%,which was higher than that of the control group of 66.67%,with statistically significant(P<0.05).The TCM symptom score of the experimental group was(6.89±3.45)points,which was lower than that of the control group(10.51±4.03)points,with statistically significant(P<0.05).In the the experimental group,the chronic inflammation score and atrophy score were all lower than those of the control group,with statistically significant(P<0.05).The PGR of the experimental group was(6.88±2.41),there was no significant difference between the control group(7.24±2.36)(P>0.05),while the level of G-17 of the experimental group was(7.31±1.32)pmol/L,which was higher than that of the control group(5.43±1.30)pmol/L,with statistically significant(P<0.05).Conclusion:Qingre Huashi prescription combined with quadruple chemotherap on the patients with chronic atrophic gastritis with erosion can help to improve the efficacy on patients,and promote the symptom improvement of the patients.

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