To investigate the clinical efficacy and value of iontoprotection combined with acupoint massage in diabetic peripheral neuropathy.Methods:A total of 210 cases of diabetic peripheral neuropathy, who were treated in Chengbei District TCM Hospital in Xining City from January 2016 to October 2018, were selected and divided into a control group and an observation group according to different treatment schemes, with 105 cases in each group.The control group was given basic treatment of western medicine, and the observation group was combined with iontoprotection of traditional Chinese medicine and acupoint massage on the basis of the control group.The treatment effects of the 2 groups were compared.Results:The total effective rate of treatment in the observation group was 97.14%, which was significantly higher than that in the control group(86.67%), and the difference between groups was statistically significant(P<0.05).After treatment, limb numbness score(1.53±0.11), limb pain score(1.34±0.12), fatigue score(1.23±0.14)and chills fear score(1.33±0.14)were scored in the observation group.After treatment, limb numbness score(2.06±0.38), limb pain score(1.96±0.34), fatigue score(1.84±0.37), and chills fear score(1.85±0.32)were scored in the control group.The differences were statistically significant(P<0.05).After treatment, ulnar nerve conduction velocity(51.68±3.75)m/s, tibial nerve conduction velocity(39.96±2.98)m/s, and common peroneal nerve conduction velocity(38.43±2.88)m/s were observed in the observation group.After treatment, ulnar nerve conduction velocity(45.32±2.86)m/s, tibial nerve conduction velocity(37.04±2.41)m/s, and common peroneal nerve conduction velocity(35.06±2.19)m/s in the control group were observed.The comparison showed statistically significant difference(P<0.05).Conclusion:The application of traditional Chinese medicine iontoprotection combined with acupoint massage in diabetic peripheral neuropathy can improve clinical efficacy, improve neurotransmitter and reduce clinical symptom score, which is worthy of clinical application.