To study the pharmacological mechanism of Achyranthes bidentata in the treatment of polycystic ovary syndrome(PCOS)by network pharmacological methods and techniques.Methods:The active components and potential targets of Achyranthes bidentata were screened by the platform of systematic pharmacological analysis of traditional Chinese medicine(TCMSP); the PCOS disease targets were obtained by querying the NCBI database to find the co-target of drugs and diseases; the gene function GO enrichment analysis and KEGG enrichment analysis were carried out by DAVID database on the co-target database; and the component-target-pathway network was constructed by Cytoscape software.Results:A total of 24 bull knee candidate active compounds were screened，and 128 targets were selected.The 22 common targets with PCOS mainly involved the AGE-RAGE signal path，NF-κB signal path，TNF signal path，etc.A total of 23 target involved in compounds，7 targets involved 5 or more compounds，ESR1 and AR involved as many as 19 compounds，as well as GSK3B(12)，ESR2(11)，PPARG(11)，ADRB2(9)or more compounds.Conclusion:Achyranthes bidentata in the treatment PCOS has the characteristics of multi-component and multi-target synergistic effects.It can play the role of anti-inflammatory，anti-tumor，regulating blood lipid，promoting microcirculation and improving insulin resistance by interfering with molecular network，biological process and signaling pathway.