| 引用本文:余丽金，肖淑，许艳.暖宫保孕丸联合二甲双胍对多囊卵巢综合征的临床效果研究[J].世界中医药,2020,(22):. |
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| 暖宫保孕丸联合二甲双胍对多囊卵巢综合征的临床效果研究 |
| Study on Clinical Effect of Nuangong Baoyu Pill Combined with Metformin on Polycystic Ovary Syndrome |
| 投稿时间：2020-09-22 |
| DOI：10.3969/j.issn.1673-7202.2020.22.019 |
| 中文关键词: 暖宫保孕 二甲双胍 多囊卵巢综合征 激素 排卵 安全性 |
| English Keywords:Nuangong Baoyu Pill Metformin Polycystic ovary syndrome Hormone Ovulation Safety |
| 基金项目:海南省自然科学领域高层次人才项目(2019RC369) |
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| 中文摘要: |
| 目的：探讨暖宫保孕丸联合二甲双胍对多囊卵巢综合征的临床效果。方法：选取2017年1月至2019年1月海南现代妇女儿童医院收治的多囊卵巢综合征患者86例作为研究对象，按照随机数字表法分为对照组和观察组，每组43例。对照组采用二甲双胍治疗，观察组采用暖宫保孕丸联合二甲双胍治疗，比较2组的应用效果。结果：治疗后观察组的卵巢体积（8.13±1.75）cm3、子宫内膜厚（0.93±0.28）cm低于对照组的（9.36±1.95）cm3、（1.14±0.36）cm(P<0.05)；治疗后观察组的促卵泡激素(FSH)（4.84±0.69）U/L、黄体生长激素(LH)（8.94±2.63）IU/L、雌二醇(E2)（70.93±3.16）pg/mL低于对照组的（5.21±0.78）U/L、（11.06±3.28）IU/L、（73.02±3.35）pg/mL(P<0.05)；观察组总有效率(90.70%)高于对照组(72.09%)(P<0.05)；观察组不良反应发生率(13.95%)与对照组(9.30%)比较差异无统计学意义(P>0.05)；观察组排卵率(88.37%)、妊娠率(83.72%)高于对照组(69.77%)、(62.79%)，妊娠早期流产率(6.98)低于对照组(25.58%)(P<0.05)。结论：暖宫保孕丸联合二甲双胍治疗多囊卵巢综合征能够有效减少子宫内膜厚度、卵巢体积，调节血清激素水平，促进排卵，降低流产风险，提升疗效，安全性良好。 |
| English Summary: |
| To investigate the clinical effect of Nuangong Baoyu Pill combined with metformin on polycystic ovary syndrome (PCOS). Methods:A total of 86 PCOS patients in Hainan Modern Women and Children's Hospital were selected as the research objects and were randomly divided into a control group and an observation group, with 43 cases in each group. The control group was treated with metformin, and the observation group was treated with Nuangong Baoyu Pill combined with metformin. The application effect of the 2 groups was compared. Results:After treatment, the ovarian volume (8.13±1.75) cm3 and endometrial thickness (0.93±0.28) cm in the observation group were lower than those in the control group (9.36±1.95) cm3 and (1.14±0.36) cm (P<0.05); after treatment, follicle stimulating hormone (FSH) (4.84±0.69) U/L, luteinizing growth hormone (LH) (8.94±2.63) IU/L, estradiol (E2) (70.93±3.16) pg/mL in the observation group were lower than those in the control group (5.21±0.78) U/L, (11.06±3.28）IU/L、（73.02±3.35）pg/mL(P<0.05). The total effective rate of the observation group (90.70%) was higher than that of the control group (72.09%) (P<0.05); the incidence of adverse reactions in the observation group (13.95%) was not significantly different than that in the control group (9.30%) (P>0.05); the ovulation rate (88.37%), pregnancy rate (83.72%) in the observation group were higher than those in the control group (69.77%) and (62.79%), and the early pregnancy abortion rate (6.98) was lower than that in the control group (25.58%) (P<0.05). Conclusion:Nuangong Baoyu Pill combined with metformin can effectively reduce endometrial thickness and ovarian volume, regulate serum hormone levels, promote ovulation, reduce the risk of abortion, improve the efficacy, with good safety. |
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