Secondary amenorrhea is one of the common and difficult and compli-cated diseases of gynecology.Its pathogenesis is complex and changeable.It always comes from delayed menstrual cycle or hypomenorrhea.It also comes from central disease or damage of operation and chemoradiotherapy.Professor XU Xin considers that the rooted pathogenesis is deficiency of spleen and kidney，the turbid-heat in Yangming meridians and damage of yin blood.Liver dysfunction is predisposing fac-tors of secondary amenorrhea.In terms of the treatment，on the bases of invigorating the kidney to replenish essense，inviograting the spleen for nourishing blood，clearing the heat-turbidity of Yanming meridian is combined with regulating Live and stamoch qi.By dispeling heat turbidity，recovering yin blood and promoting yang qi，substances that maintain male and female sexual function regains and men-struation returns to normal.