| 引用本文:鞠军亮，孟令坡，董晓波，安俊岐.通心络胶囊对颅内动脉粥样硬化的临床观察[J].世界中医药,2020,(23):. |
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| 通心络胶囊对颅内动脉粥样硬化的临床观察 |
| Clinical Observation of Tongxinluo Capsule on Intracranial Atherosclerosis |
| 投稿时间：2019-07-20 |
| DOI：10.3969/j.issn.1673-7202.2020.23.025 |
| 中文关键词: 颅内动脉粥样硬化 通心络胶囊 脂代谢 凝血功能 炎性反应递质 动脉狭窄程度 心脑血管不良事件 临床疗效 |
| English Keywords:Intracranial atherosclerosis Tongxinluo Capsule Lipid metabolism Coagulation function Cytokines Degree of arterial stenosis Adverse cardiovascular and cerebrovascular events Clinical efficacy |
| 基金项目:河北省重点研发计划项目(172777213) |
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| 中文摘要: |
| 目的：观察通心络胶囊治疗颅内动脉粥样硬化患者临床疗效及对患者疾病相关指标的影响。方法：选取2017年1月至2018年12月河北以岭医院收治的颅内动脉粥样硬化患者200例作为研究对象，按照随机数字表法分为对照组和观察组，每组100例。2组患者均予以常规治疗，观察组再予以通心络胶囊治疗。比较2组患者治疗前、治疗后颅内动脉狭窄程度分级构成、脂代谢、凝血功能、颅内血流动力学、炎性反应递质水平。比较2组患者治疗期间心脑血管不良事件、药物不良反应率。结果：2组患者治疗后颅内动脉轻度狭率、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）、收缩期峰值血流速度（Vs）、舒张期血流速度（Vd）、平均血流速度（Vm）、脉动指数（PI）、阻力指数（SI）、S/D、白细胞介素-6（IL-6）、肿瘤坏死因子-ɑ（TNF-ɑ）、超敏C反应蛋白（hs-CＲP）水平改善幅度均较对照组高，且观察组心脑血管不良事件率低于对照组,差异有统计学意义（P<0.05）。结论：通心络胶囊可有效减轻颅内动脉狭窄程度，且安全性高，可能与通心络胶囊对患者脂代谢、凝血功能、炎性反应的改善作用有关。 |
| English Summary: |
| To observe the clinical effects of Tongxinluo Capsule in the treatment of patients with intracranial atherosclerosis and its influence on disease-related indexes of patients.Methods:A total of 200 patients with intracranial atherosclerosis admitted in Hebei Yiling Hospital from Jan.2017 to Nov.2018 were randomly divided into a control group and an observation group according to random number table，with 100 cases in each group.Both groups were given routine treatment，and the observation group was given Tongxinluo Capsule for the treatment.Before and after treatment，graded composition of intracranial artery stenosis，lipid metabolism，coagulation function，intracranial hemodynamics and levels of cytokines were compared between the 2 groups.The adverse events of cardiovascular and cerebrovascular diseases and rate of adverse drug reactions were compared between the 2 groups.Results:After treatment，the rate of slight stenosis of intracranial artery，TC，LDL，TG，HDL，PT，APTT，TT，FIB，Vs，Vd，VM，PI，SI，S/D，IL-6，TNF-α，hs CRP in the 2 groups were higher than those in the control group，and the rate of cardiovascular and cerebrovascular adverse events in the observation group was lower than that in the control group(P<0.05).Conclusion:Tongxinluo Capsule can effectively reduce the degree of intracranial artery stenosis and has high safety，which may be related to the improvement of lipid metabolism，coagulation function and inflammatory state of Tongxinluo Capsule. |
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