To explore and analyze the mechanism of Radix Salviae Miltiorrhizae-Flos Carthami herb pair on the treating coronary heart disease through network pharmacology.Methods:The TCMSP network database was used to screen and mine the main effective components and targets of Danshen-Honghua，and the Cytoscape3.7.2 software was used to construct the network diagram of traditional Chinese medicine components and targets.The OMIM online analysis platform was used to mine the relevant targets of coronary heart disease.Based on STRING database，the protein-protein interaction (PPI) network diagram (PPI) of Danshen-Honghua for CHD treatment was constructed.Then topological analysis was performed to screen out the core targets of Danshen-Honghua for CHD treatment.Metascape database was used to analyze the biological pathway and enrichment of drug-disease intersection targets.Results:The network diagram of Danshen-Honghua and target contains 87 active components and 1693 corresponding targets.The core targets include TNF，1L1B，MPO，VCAM1，VEGFR，MMP3，etc.Conclusion:It can be seen that the main target participation of Danshen-Honghua in treating coronary heart disease is related to fluid shear stress and atherosclerosis，active oxygen metabolism process，positive regulation of DNA binding transcription factor activity，positive regulation of protein complex assembly，regulation of cell activation，etc.Among them，the largest amount of targets were concentrated in fluid shear stress and atherosclerosis，which further illustrated that Danshen-Honghua had more pathways and more complicated mechanisms in treating coronary heart disease，and also suggested that this biological process might be an important direction for future research on Danshen-Honghua in treating CHD.