To investigate the effect of Shengyang Yiwei Decoction on the chemotherapy in advanced gastric cancer patients with wet resistance syndrome of yang deficiency.Methods:A total of 86 patients with chemotherapy for advanced gastric and wet resistance syndrome of yang deficiency admitted to Tangdu Hospital,Air Force Medical University from October 2017 to August 2019 were selected and randomly divided into the conventional group(43 patients,conventional chemotherapy)and the study group(43 patients,conventional chemotherapy＋Shengyang Yiwei Decoction plus or minus).The traditional Chinese medicine score,antitumor efficacy,the levels of tumor markers,T lymphocyte subsets before and after treatment were compared between the 2 groups.The occurrence of adverse reactions in the 2 groups was compared.Results:After treatment,the main symptom score,secondary symptom score and total score of the 2 groups were all reduced(P<0.05).The main score,secondary score and total score of the study group were all lower than those of the conventional group(P<0.05).The distribution of anti-tumor efficacy was significantly different between the 2 groups(P<0.05),and the effective rate of the study group was higher than that of the conventional group(P<0.05).The levels of saccharide antigen 125(CA125),saccharide antigen 19-9(CA19-9),oncoembryonic antigen(CEA)and cytokeratin 19 fragment antigen 21-1(CY-FRA21-1)were all reduced after treatment in the 2 groups(P<0.05).The levels of CA125,CA19-9,CEA and CY-FRA21-1 in the study group were all lower than those in the conventional group(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in the 2 groups increased after treatment(P<0.05),and the levels of CD3+,CD4+ and CD4+/CD8+ in the study group were all higher than those in the conventional group(P<0.05).There was no significant difference in the incidence of nausea,vomiting,hair loss,anemia and thrombocytopenia between the 2 groups(P> 0.05).Conclusion:For thechemotherapy for advanced gastric cancerpatients with wet resistance syndrome of yang deficiency,the treatment of Shengyang Yiwei Decoction can significantly reduce the patient's condition,enhance the anti-tumor efficacy,reduce the level of tumor markers,improve the immune function of T cells and good safety.