| 引用本文:刘贵阳，辜勇，廖学东，黄雪莲，蒋传斌，王琴.金水宝胶囊对糖尿病肾病并发性功能障碍男性的治疗效果以及安全性初步分析[J].世界中医药,2020,(24):. |
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| 金水宝胶囊对糖尿病肾病并发性功能障碍男性的治疗效果以及安全性初步分析 |
| Preliminary Analysis of the Therapeutic Effect and Safety of Jinshuibao Capsule on Men with Diabetic Nephropathy and Sexual Dysfunction |
| 投稿时间：2020-11-12 |
| DOI：10.3969/j.issn.1673-7202.2020.24.017 |
| 中文关键词: 金水宝胶囊 糖尿病肾病 性功能障碍 高血糖 肾功能衰竭 |
| English Keywords:Jinshuibao Capsule Diabetic nephropathy Sexual dysfunction Hyperglycemia Renal failure |
| 基金项目:四川省中医药科技计划项目（ZY-355021） |
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| 中文摘要: |
| 目的：探讨金水宝胶囊辅助治疗糖尿病肾病并发性功能障碍的效果。方法：选取2017年6月至2020年5月眉山市第二人民医院收治的糖尿病肾病并发性功能障碍的男性患者122例作为研究对象。按照随机数字表法分为对照组和观察组，每组61例。对照组给予缬沙坦。观察组给予缬沙坦+金水宝胶囊。记录2组治疗前后的IIFE-5评分、性激素水平［睾酮（T）、黄体生成素（LH）、卵泡刺激素（FSH）］、血管内皮素（ET-1）、血管紧张素（AngⅡ）、空腹血糖、收缩压、舒张压。记录2组治疗过程中的不良反应情况。结果：观察组的治疗总有效率高于对照组（P<0.05）。2组治疗后的IIFE-5评分、T、LH均升高，2组治疗后的ET-1、AngⅡ、空腹血糖、收缩压、舒张压均降低，观察组的IIFE-5评分、T、LH高于对照组，观察组的ET-1、AngⅡ、空腹血糖、收缩压、舒张压低于对照组（P<0.05）。结论：在糖尿病肾病合并性功能障碍的男性患者中，采用金水宝胶囊联合缬沙坦的治疗策略，有助于提升阴茎勃起功能恢复，改善性激素水平以及血管功能，降低血糖以及血压水平。 |
| English Summary: |
| To explore the effect of Jinshuibao Capsule on the auxiliary treatment of diabetic nephropathy complicated with sexual dysfunction.Methods:A total of 122 male patients with diabetic nephropathy complicated with sexual dysfunction admitted to The Second People's Hospital of Meishan City from June 2017 to May 2020 were selected as the research objects and were randomly divided into a control group and an observation group，with 61 cases in each group.The control group was given valsartan.The observation group was given valsartan and Jinshuibao Capsule.The IIFE-5 score，sex hormone levels ［testosterone (T)，luteinizing hormone (LH)，follicle stimulating hormone (FSH)］，endothelin (ET-1)，angiotensin (Ang Ⅱ)，fasting blood glucose，systolic blood pressure and diastolic blood pressure were recorded before and after treatment.The adverse reactions during the treatment were recorded.Results:The total effective rate of the observation group was higher than that of the control group (P<0.05).After treatment，IIFE-5 score，LH were increased，ET-1，Ang Ⅱ，fasting blood glucose，systolic blood pressure and diastolic blood pressure were decreased in both groups.Life-5 score，and LH of observation group were higher than those of control group，and ET-1，Ang Ⅱ，fasting blood glucose，systolic blood pressure and diastolic blood pressure in observation group were lower than those in control group (P<0.05).Conclusion:In male patients with diabetic nephropathy and sexual dysfunction，the treatment strategy of Jinshuibao Capsule combined with valsartan can help improve the recovery of erectile function of the penis，improve the level of sex hormones and vascular function，reduce blood sugar and blood pressure. |
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