In recent years，with the rapid development of the economy and society and the complexity and diversification of social relations，traumatic events such as natural disasters，violent crimes and sexual assaults have frequently occurred.Attention to post-traumatic stress disorder (PTSD) is increasing year by year.How to prevent PTSD becomes an important research topic.As a treasure of traditional Chinese medicine，acupuncture has rich experience and unique advantages in the prevention and treatment of mental diseases.Clinical studies have confirmed that acupuncture can effectively improve the symptoms related to PTSD，but its internal mechanism is still unclear.Based on this，this paper reviewed relevant studies published in recent years，in an attempt to preliminarily reveal the intrinsic neurobiological mechanism of acupuncture treatment for PTSD and provide reference for clinical treatment.