Based on the“lung and large intestine”compound Cangshu Formula to regulate intestinal flora on the effects of chronic obstructive pulmonary disease(COPD).Methods:A total of 110 patients with COPD admitted to Qinghai Traditional Chinese Medicine Hospital from Feb 2016 to Feb 2019 were divided into a control group and a study group,with 55 cases in each group.The control group was treated with routine Western medicine,and the study group was treated with compound Cangshu Formula.The changes of inflammatory factors,immune function,lung function,clinical symptoms and intestinal flora were observed and compared before and after treatment.Results:After treatment,the patients in the observation group in terms of CD3+,CD4+,CD4+/CD8+,CD8+,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-8,forced expiratory volume(FEV1)/forced vital capacity(FVC),maximum ventilation(MVV),6-minute walking distance(6MWD),Bifidobacterium,Lactobacillus,Bacteroides,B/E and clinical symptom scores and the improvement effects,were better than that of the control group(P<0.05).Conclusion:Compound Cangshu Formula can improve the clinical symptoms of COPD by regulating intestinal flora,inhibiting inflammation,improving lung function and immune function.