| 引用本文:张婧，李靖，张海力，曲海顺，张献之，程亚清，张正媚，黄佳钦.尿毒清颗粒联合血管紧张素系统阻滞剂治疗糖尿病肾病的Meta分析[J].世界中医药,2021,(02):. |
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| 尿毒清颗粒联合血管紧张素系统阻滞剂治疗糖尿病肾病的Meta分析 |
| Meta-analysis of Niaoduqing Granules Combined with ACEI/ARB in the Treatment of Diabetic Nephropathy |
| 投稿时间：2019-03-21 |
| DOI：10.3969/j.issn.1673-7202.2021.02.016 |
| 中文关键词: ACEI/ARB 联合用药 Meta分析 尿毒清颗粒 RAAS系统阻滞剂 糖尿病肾病 中医药 |
| English Keywords:ACEI/ARB Combination of drugs Meta-analysis Niaoduqing Granules RAAS system blocker Diabetic nephropathy Traditional Chinese medicine |
| 基金项目:国家自然科学基金青年科学基金项目（81603570） |
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| 中文摘要: |
| 目的：系统评价尿毒清颗粒联合RAAS系统阻滞剂治疗糖尿病肾病的疗效。方法：运用计算机检索CNKI、万方、VIP、Pubmed、Embase及Cochrane Library中关于尿毒清颗粒联合RAAS系统阻滞剂治疗糖尿病肾病随机对照试验（RCT）的研究文献。采用RevMan5.3软件对符合本次研究的文献中所需要的数据进行Meta分析。结果：最终收入15篇随机对照试验，共1 063例患者纳入分析，其中联合治疗538例，对照组525例。Meta分析结果显示尿毒清颗粒联合RAAS系统阻滞剂组在临床缓解率[OR=2.92，95%CI(1.76-4.86)]、24 h尿蛋白定量[MD 0.71，95%CI(0.28-1.14)]、UAER[MD 41.13，95%CI(26.66-55.59)]。但尿毒清颗粒联合RAAS系统阻滞剂观察组在降低血清尿素氮[MD-0.86，95% CI(0.05-1.68,P=0.02)]、降低空腹血糖[MD-0.03，95%CI(-0.15-0.09)，P=0.61]方面无治疗优势。2组不良事件发生率差异无统计学意义[RR=2.34，95%CI(0.69-7.95),P=0.17]。结论：尿毒清颗粒联合RAAS系统阻滞剂可能与单独使用RAAS系统阻滞剂一样安全，在提高总有效率、降低24 h尿蛋白定量及UAER方面具有优势。但由于此次纳入分析的文献质量偏低，未来更需要多中心，大样本，研究设计更严谨的随机双盲实验做进一步验证。 |
| English Summary: |
| To systematically evaluate the efficacy of Niaoduqing Granules combined with ACEI/ARB in the treatment of diabetic nephropathy.Methods:Computer-researched literature on diabetic nephropathy randomized controlled trials ( RCT ) in the treatment of Niaoduqing Granules combined with ACEI/ARB was screened in CNKI,Wanfang,VIP,Pubmed,Embase,and Cochrane Library.A Meta-analysis of the data required in the literature in accordance with this study was performed using revman 5.3 software.Results:A total of 15 randomized controlled trials were finally analyzed and 1 063 patients were adopted for analysis,including 538 patients receiving the combination treatment and 525 patients in the control group.The results of Meta-analysis showed that the clinical remission rate of Niaoduqing Granule combined with ACEI/ARB was significantly better than of the control group [OR=2.92,95% CI ( 1.76-4.86 )].The treatment combined with Niaoduqing granule decreased the 24-hour urinary protein quantitation [MD 0.71,95% CI ( 0.28-1.14 )] and UAER [MD 41.13,95% CI ( 26.66-55.59 )] levels.However,the combination group had no treatment advantage on reducing serum urea nitrogen [MD 0.86,95% CI ( 0.05-1.68 ),P=0.02] and fasting blood glucose ( MD-0.03,95% CI (-0.15-0.09 ),P=0.61].And there was no significance in adverse events between 2 groups [RR=2.34,95% CI ( 0.69-7.95 ),P=0.17].Conclusion:Niaoduqing Granules-ACEI/ARB combination group maybe as safe as using ACEI/ARB alone,and the combination had an advantage in improvement in total effective rate,reducing of 24-hour urinary protein quantitation and UAER.However,due to the low quality of the literature included in this analysis,more centers and large samples are needed in the future.A more rigorous randomized double-blind trial was designed for further validation. |
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