| 引用本文:常雪1，陈晓婧1，张旭东1，张超伟1，李永乐1，白燕2.中医药调控细胞自噬防治消化系统疾病研究现状[J].世界中医药,2021,(03):. |
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| 中医药调控细胞自噬防治消化系统疾病研究现状 |
| Research Status of Chinese Medicine Regulating Autophagy to Prevent and Cure Digestive System Diseases |
| 投稿时间：2020-03-21 |
| DOI：10.3969/j.issn.1673-7202.2021.03.030 |
| 中文关键词: 消化系统疾病 自噬 中医药 ULK1蛋白激酶复合体 Vps34-Beclin1 Ⅲ型PI3K复合体 mAtg9 Atg5-Atg12-Atg16连接系统 LC3连接系统 综述 |
| English Keywords:Digestive system diseases Autophagy Traditional Chinese medicine ULK1 protein kinase complex Vps34-Beclin1 Type Ⅲ PI3K Complex mAtg9 Atg5-Atg12-Atg16 junction system LC3 junction system Review |
| 基金项目:内蒙古自然科学基金面上项目(2018MS08023)——基于线粒体信号通路探究加味黄芪建中汤对慢性萎缩性胃炎大鼠胃黏膜细胞凋亡的调控机制,负责人:李永乐;内蒙古医科大学科技百万项目(YKD2O17KJBW005)——基于TRAIL通路探究加味黄芪建中汤对慢性萎缩性胃炎大鼠胃黏膜细胞增殖与凋亡失衡的影响及机制,负责人:李永乐;内蒙古医科大学人才团队项目(NYTD-2017006)——内蒙古医科大学中医临床实训人才团队,负责人:李永乐 |
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| 中文摘要: |
| 消化系统疾病是临床中常见病、多发病,临床表现纷繁复杂,疾病之间相互关联,严重影响患者生命质量。细胞自噬是维护胃黏膜细胞稳态的重要因素,是导致消化系统疾病发病的重要环节。中医药作为临床防治消化系统疾病的重要干预措施之一,其防治作用及机制成为近年来研究的重要方向。本文通过收集相关文献资料,重点从ULK1蛋白激酶复合体、Vps34-Beclin1和Ⅲ型PI3K复合体、mAtg9、Atg5-Atg12-Atg16连接系统和LC3连接系统中具体信号通路及相关蛋白分析近年来中医药对消化系统疾病细胞自噬的调控的研究现状,以期发现中医药调节自噬对于细胞保护的作用,从而对于中医药防治消化系统疾病提供依据。 |
| English Summary: |
| Digestive system diseases are common and frequently-occurring diseases in clinical practice.The clinical manifestations are complex and complicated.The diseases are interrelated，which seriously affects the quality of life of patients.Cell autophagy is an important factor in maintaining the homeostasis of gastric mucosal cells and an important link in the pathogenesis of digestive system diseases.As one of the important intervention measures for clinical prevention and treatment of digestive system diseases，Traditional Chinese medicine(TCM)has become an important research direction in recent years.This paper collect relevant literature and focuses on the analysis of specific signal pathways and related proteins in the ULK1 protein kinase complex，Vps34-Beclin1 and type Ⅲ PI3K complex，mAtg9，Atg5-Atg12-Atg16 connection system and LC3 connection system in recent years.The current status of research on the regulation of digestive system disease cell autophagy，with a view to discovering the role of TCM in regulating autophagy on cell protection，so as to provide a basis for the prevention and treatment of digestive system disease by Chinese medicine. |
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