| 引用本文:张元元1，2，李旭2，廖子君2，王玉珍2.基于网络药理学预测苦参治疗肝癌的分子机制[J].世界中医药,2021,(05):. |
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| 基于网络药理学预测苦参治疗肝癌的分子机制 |
| Molecular Mechanism of Sophora Flavescens in the Treatment of Liver Cancer Based on Network Pharmacology |
| 投稿时间：2020-03-05 |
| DOI：10.3969/j.issn.1673-7202.2021.05.013 |
| 中文关键词: 网络药理学 苦参 肝癌 机制 活性成分 靶点 富集分析 信号通路 |
| English Keywords:Network pharmacology Sophora flavescens Liver cancer Mechanism Active ingredients Target Enrichment analysis Signal pathway |
| 基金项目:CSCO中医药肿瘤研究基金项目（Y-L2018-002） |
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| 中文摘要: |
| 目的：运用网络药理学的方法，探讨苦参治疗肝癌的作用机制。方法：通过中医药系统药理学数据库分析平台（TCMSP）筛选出苦参活性成分及作用靶点；在OMIM和Genecards中获取疾病靶点。通过R语言对基因进行匹配并绘制韦恩图；在String网站构建活性成分-蛋白质-蛋白质相互作用网络图；Cytoscape 3.6.1软件构建成分-靶点网络；通过R软件进行GO富集分析和KEGG通路富集分析。结果：共筛选出45个活性成分和176个潜在作用靶点；GO及KEGG功能富集显示苦参主要影响PI3K/Akt/mTOR通路及HIF-1a等信号通路。结论：苦参可能通过影响PI3K/Akt/mTOR通路及HIF-1a等信号通路，从而调控肝癌细胞侵袭及转移。 |
| English Summary: |
| To explore the mechanism of Sophora flavescens in the treatment of liver cancer by means of network pharmacology.Methods:First,the active ingredients and targets of Sophora flavescens were screened through the TCMSP platform; then the disease targets were obtained from OMIM and Genecards.We matched genes through R language and draw a Venn diagram; then constructed an active ingredient-protein interaction network diagram on the String website; constructed a component-target network with Cytoscape 3.6.1 software; performed GO enrichment analysis and KEGG pathway enrichment analysis through R software.Results:A total of 45 active ingredients and 176 potential targets were screened; GO and KEGG function enrichment showed that Sophora flavescens mainly affected PI3K/Akt/mTOR pathway and HIF-1a signal pathways.Conclusion:Sophora flavescens may regulate the invasion and metastasis of liver cancer cells by affecting the PI3K/Akt/mTOR pathway and HIF-1a signaling pathways. |
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