To research the mechanism of emodin in the treatment of ischemic stroke based on network pharmacology and molecular docking.Methods:Emodin targets for ischemic stroke were obtained by using SymMap，TCMSP，OMIM and Drugbank databases，and the format was unified and non-human targets were removed by Uniprot database.Then AlzData database was used to analyze the distribution and expression of emodin targets in brain cells for cerebral ischemia stroke.KEGG pathway and GO enrichment analysis was performed on the target of emodin for ischemic stroke using DAVID database to obtain the relevant pathway.Results:There were 10 potential targets for emodin in the treatment of ischemic stroke，which were CASP3，KDR，PTGS1，TNF，MMP9，PRKCE，PTGS2，MYC，TP53.They were expressed in astrocytes，microglia and endothelial cells in a different degrees.There were 12 KEGG related enrichment pathways，14 GO biological process enrichment items，3 GO cell component enrichment items，and 2 GO cell functional enrichment items related to ischemic stroke，and it had a good combination with CASP3，KDR，PTGS1，TNF and MMP9.Conclusion:Emodin may play a role in the treatment of ischemic stroke mainly through CASP3，KDR，PTGS1，TNF，MMP9 acting on apoptosis pathways and inflammation-related pathways.