| 引用本文:李吉庆，林道斌，张永杰.黄连-葛根药对治疗2型糖尿病的网络药理学研究[J].世界中医药,2021,(06):. |
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| 黄连-葛根药对治疗2型糖尿病的网络药理学研究 |
| Mechanisms of the Drug Pair Coptis Chinensis-Pueraria Lobata in the Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology |
| 投稿时间：2019-10-09 |
| DOI：10.3969/j.issn.1673-7202.2021.06.007 |
| 中文关键词: 网络药理学 黄连 葛根 2型糖尿病 作用机制 前列腺素G/H合酶1 前列腺素G/H合酶2 PI3K-Akt信号通路 |
| English Keywords:Network pharmacology Coptis chinensis Pueraria lobata Type 2 diabetes Mechanism of action Prostaglandin G / H synthase 1 Prostaglandin G / H synthase 2 PI3K Akt signaling pathway |
| 基金项目:国家中医药管理局“张永杰全国名中医传承工作室”项目（琼财社［2018］331）；海南省人才引进与培养项目（R100028.401）；海南省治未病中医重点专科建设项目（琼卫中医函〔2019〕9号） |
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| 中文摘要: |
| 目的：运用网络药理学研究方法对黄连-葛根药对治疗2型糖尿病(T2DM)的作用机制进行分析。方法：采用中药系统药理学分析平台（Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform，TCMSP）筛选出黄连-葛根（Coptis Chinensis-Pueraria Lobata，C-P）药对的有效活性成分及作用靶点蛋白，再使用Unipro数据库将筛选出的靶点蛋白转换为基因名，通过GeneCards数据库收集T2DM疾病基因，然后对药物作用基因及疾病相关基因进行韦恩(Venn)分析，寻找交集靶点，用交集靶点与对应活性成分构建活性成分-靶点相互作用网络，并对交集基因进行GO功能富集分析和KEGG通路富集分析。结果：研究得到13个作用于T2DM疾病靶点的活性成分和146个作用靶点，GO功能富集分析确定了284个条目，KEGG通路分析共发现77条作用通路。结论：本研究结果初步探讨了C-P药对治疗T2MD的基本药理作用及其机制，并为进一步的试验研究奠定了良好的基础。 |
| English Summary: |
| To analyze the mechanism of the drug pair Coptis chinensis-Pueraria lobata in the treatment of type 2 diabetes mellitus(T2MD)by using the method of network pharmacology.Methods:The active components and target proteins of the drug pair Coptis chinensis-Pueraria lobata(C-P)were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)，and the target proteins were screened by Unipro database and converted into gene names.The disease gene of T2MD was collected through GeneCards database.Then the drug-acting genes and disease-related genes were analyzed by vnne to find the intersecting targets，with which plus their corresponding active components an active component-target interaction network was constructed.GO function enrichment analysis and KEGG pathway enrichment analysis of the intersecting genes were also carried out.Results:A total of 13 active components acting on T2MD and 146 effect targets were identified，284 items were identified by GO functional enrichment analysis，and 77 pathways were identified by KEGG pathway analysis.Conclusion:The results of this study preliminarily discussed the basic pharmacological effects and mechanisms of C-P drugs on the treatment of T2MD,and laid a good foundation for further experimental research. |
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