| 引用本文:赵荣华1，王道涵2，曲天歌3，孙静1，包蕾1，高英杰1，崔晓兰1.柏艾胶囊对不同类型高血压模型降压作用的研究[J].世界中医药,2021,(06):. |
|
| 柏艾胶囊对不同类型高血压模型降压作用的研究 |
| Study on the Antihypertensive Effect of Boai Capsule on Different Types of Hypertension Model |
| 投稿时间：2019-09-19 |
| DOI：10.3969/j.issn.1673-7202.2021.06.010 |
| 中文关键词: 柏艾胶囊 自发性高血压模型 卒中型自发性高血压模型 肾动脉狭窄性高血压模型 靶器官 不良反应 肝阳上亢型 肝肾阴虚 |
| English Keywords:Boai Capsule Spontaneous hypertension model Stroke medium spontaneous hypertension model Renal artery stenosis hypertension model Target organ Toxic and side effects Hyperactivity of liver yang Deficiency of liver and kidney yin |
| 基金项目:国家自然科学基金面上项目(81774204)——疏风解毒胶囊对流感病毒性肺炎病理损伤修复作用的生物学机制研究 |
|
| 摘要点击次数: 319 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的:探讨柏艾胶囊对自发性高血压模型、卒中型自发性高血压模型及肾动脉狭窄性高血压模型大鼠血压的影响。方法:将大鼠随机分为正常血压大鼠(wky)对照组/假手术组、模型对照组、卡托普利阳性药对照组(5.4 mg/kg)、柏艾胶囊大、中、小剂量组(6.42 g/kg、3.24 g/kg、1.62 g/kg),采用自动血压记录仪测量给药前后大鼠尾动脉血压。结果:柏艾胶囊大、中、小剂量组(6.42 g/kg、3.24 g/kg、1.62 g/kg)均可不同程度降低SHR模型大鼠的血压值,与模型对照组比较,给药2周后各给药组血压值降低,且差异有统计学意义(P<0.01),停药4周后血压值仍见不同程度降低,且差异有统计学意义(P<0.01);柏艾胶囊大、中剂量给药组(6.42 g/kg、3.24 g/kg)可不同程度降低SHRsp模型大鼠血压值,与模型对照组比较,给药1周后血压值明显降低,且差异有统计学意义(P<0.01),停药4周后柏艾胶囊大剂量组(6.42 g/kg)血压值仍显著降低,且与模型对照组比较，差异有统计学意义(P<0.01);柏艾胶囊大、中、小剂量组(6.42 g/kg、3.24 g/kg、1.62 g/kg)均可不同程度降低肾动脉狭窄模型高血压大鼠血压值,与模型对照组比较,给药1周后,各给药组血压值降低,且差异有统计学意义(P<0.01)。结论:柏艾胶囊具有降低原发性高血压和肾性高血压的作用。 |
| English Summary: |
| To evaluate Boai Capsule on rat blood pressure effects of spontaneously hypertensive model，type of spontaneously hypertensive stroke model，and renal artery stenosis hypertensive model.Methods:Rats were randomly assigned into a wky group or sham-operation group，a model control group，a captopril positive medicine control group (5.4 mg/kg)，a large dose，a medium dose and a low dose of Boai Capsule group (6.42 g/kg，3.24 g/kg，1.62 g/kg).Before and after dosing Bo-Ai Capsule，the rat tail artery blood pressure was measured by using automatic blood pressure recorder.Results:The large，medium，and low dose groups (6.42 g/kg，3.24 g/kg，1.62 g/kg) of Boai Capsule can reduce the blood pressure value of SHR model rats to varying degrees.Compared with the model control group，after 2 weeks of administration，the blood pressure value of each administration group decreased，and the difference was statistically significant (P<0.01).The blood pressure value still decreased to varying degrees after stopping the drug for 4 weeks，and the difference was statistically significant (P<0.01).The large and medium dose administration group of Boai Capsule (6.42 g/kg，3.24 g/kg) can reduce the blood pressure value of SHRsp model rats to different degrees.Compared with the model control group，the blood pressure value was significantly reduced after 1 week of administration，and the difference was statistically significant (P<0.01).The blood pressure value of the large dose of Boai Capsule group (6.42 g/kg) was still significantly reduced after 4 weeks of discontinuation，and the difference was statistically significant compared with the model control group (P<0.01).Compared with model group，the blood pressure of renal artery stenosis hypertensive model rats decreased significantly in large，medium and low dose groups (6.42 g/kg、3.24 g/kg，1.62 g/kg) of Boai Capsule after dosing one week and the difference was statistically significant (P<0.01).Conclusion:Boai Capsule had effects of decreasing blood pressure of spontaneously hypertensive and renal artery stenosis hypertensive models. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
