| 引用本文:吴瑞艳1，胡光1，崔淑华1，张悦1，王芳1，张宁2.肾康宁胶囊联合用药治疗肾阳虚证导致排尿功能障碍的临床研究[J].世界中医药,2021,(06):. |
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| 肾康宁胶囊联合用药治疗肾阳虚证导致排尿功能障碍的临床研究 |
| Clinical Study of Shenkangning Capsule Combined with Medication in the Treatment of Urinary Dysfunction Caused by Renal Yang Deficiency Syndrome |
| 投稿时间：2019-09-25 |
| DOI：10.3969/j.issn.1673-7202.2021.06.021 |
| 中文关键词: 肾阳虚 肾康宁胶囊 南瓜籽花粉 葡萄糖酸锌 尿频 尿急 尿失禁 |
| English Keywords:Shenyang deficiency Shenkangning Capsule Pumpkin seed pollen Zinc gluconate Urinary frequency Urinary urgency Urinary incontinence |
| 基金项目:黑龙江省自然科学基金项目面上项目（H201328） |
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| 中文摘要: |
| 目的：评价肾康宁胶囊联合用药治疗肾阳虚证患者的临床疗效和安全性。方法：选取2018年5月至2018年10月间黑龙江中医药大学附属第二医院等收治的肾阳虚型患者360例作为研究对象，以区组随机法均分为对照组、联合观察组和葡萄糖酸锌组，每组120例，并给予对应方案进行治疗。记录3组患者在治疗前、治疗4周后、治疗8周后的夜尿量、尿频（日尿）次数、尿失禁现象、尿急次数，进行中医证候的量化评分，评估3组的临床总有效率及单项症状的消失率、生命质量和不良反应等。结果：3组患者在治疗后其夜尿、尿失禁、尿频、尿急的中医证候量化积分均优于治疗前（P<0.01）。患者的总有效率如下：治疗4周后分别为联合观察组74.34%、葡萄糖酸锌组59.32%、对照组56.25%，治疗8周后分别为联合观察组92.92%、葡萄糖酸锌组77.12%、对照组63.39%。结论：肾康宁胶囊联合用药治疗肾阳虚排尿疾病患者疗效显著，可以明显减少夜尿和日尿次数，改善尿失禁、尿频、尿急症状，提高患者生命质量，且安全可靠。 |
| English Summary: |
| To evaluate the clinical efficacy and safety of Shenkangning Capsule in the treatment of kidney yang deficiency syndrome.Methods:A total of 360 patients with kidney yang deficiency in the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from May 2018 to October 2018 were selected as the research objects and were randomly divided into 3 groups：a control group，a combined treatment group and a zinc gluconate group.The 3 groups were given the corresponding plan for treatment.The nocturnal urine volume，frequency(daily urine)，urinary incontinence and urgency were recorded before treatment，4 weeks after treatment and 8 weeks after treatment.The quantitative score of traditional Chinese medicine(TCM)syndrome was performed，and the clinical total effective rate，disappearance rate of single symptom，quality of life and adverse reactions of the 3 groups were evaluated.Results:After treatment，the scores of TCM syndrome of nocturia，urinary incontinence，frequency of urination and urgency in 3 groups were better than those before treatment(P<0.01).The total effective rates were as follows：74.34% in the combined treatment group，59.32% in the zinc gluconate group and 56.25% in the control group after 4 weeks of treatment，and 92.92% in the combined treatment group，77.12% in the zinc gluconate group and 63.39% in the control group after 8 weeks of treatment.Conclusion:Shenkangning Capsule combined with medication in the treatment of urinary disease with kidney yang deficiency has significant curative effect，can significantly reduce the number of night urine and daily urine，improve the symptoms of urinary incontinence，frequency and urgency，improve the quality of life of patients，which is safe and reliable. |
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