The main symptoms of the cramp are limb blood impeding spasm and pain such as torsion.It often manifests as the main symptom or concurrent symptom in clinical practice.Professor LI thought that the pathogenesis of cramp，which sited in liver and spleen，was in connection with bile heat phlegm disturbance，excess-fire of the liver，spleen qi deficiency，yin-fluid deficiency，and disharmony between nutritive qi and defensive qi.On the basis of prescription classified by therapeutic methods，Professor LI treated the disease with Fructus Chaenomelis and Radix Paeoniae by law with high curative effect.Five year-clinical case reports were collected in this research as clinical references for clinical treatment.