| 引用本文:郭礼1，周铖1，杨林2，司海龙3，肖海娟3.基于健脾法调节大肠癌肠道微生态的研究进展[J].世界中医药,2021,(06):. |
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| 基于健脾法调节大肠癌肠道微生态的研究进展 |
| Research Progress on Regulating Intestinal Microecology of Colorectal Cancer by Strengthening Spleen |
| 投稿时间：2020-06-08 |
| DOI：10.3969/j.issn.1673-7202.2021.06.029 |
| 中文关键词: 健脾法 大肠癌 肠道微生态 脾虚证 调节 防治 研究进展 |
| English Keywords:Therapy of strengthening spleen Colorectal cancer Intestinal microecology Spleen deficiency syndrome Adjustment Prevention and treatment Research progress |
| 基金项目:陕西省自然科学基础研究计划-面上项目(2020JM-591)——肠胃清通过ADAM-17介导结肠癌西妥昔单抗耐药的分子机制,负责人:肖海娟;陕西中医药大学“益气健脾法防治消化系肿瘤”创新团队(2019-YL06) |
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| 中文摘要: |
| 近年来很多研究发现大肠癌的发生与肠道菌群失调相关,通过调节肠道菌群可抑制大肠癌细胞的增殖,降低大肠癌的发病率。中医认为大肠癌基本病机为脾气亏虚,运化失常,气血生化乏源,正气渐衰,邪毒留聚,日久形成肿瘤,而相关研究表明肠道菌群的平衡与失调能够反映脾脏功能状态,在消化、吸收、免疫方面,二者关系密不可分,因此在大肠癌的治疗过程中,通过健脾法调节肠道菌群紊乱发挥着重要作用。现就健脾法调节肠道微生态的研究进展做,为进一步研究临床预防及治疗大肠癌提供参考。 |
| English Summary: |
| In recent years，many studies have found that the occurrence of colorectal cancer is closely related to the intestinal flora imbalance.By adjusting the intestinal flora，it can inhibit the proliferation of colorectal cancer cells and reduce the incidence of colorectal cancer.Traditional Chinese medicine believes that the basic pathogenesis of colorectal cancer is deficiency of spleen qi leading to the disorder of transportation and transformation and lack of the origin of producing qi and blood，declining healthy qi resulting in retention of pathogenic toxin，and the formation of tumors over time.And related studies show that the balance and imbalance of intestinal flora can reflect the functional status of the spleen.The two are inseparable in terms of digestion，absorption，and immunity.Therefore，in the treatment of colorectal cancer，the therapy of strengthening spleen plays an important role in regulating the disorder of the intestinal flora.This article reviews the research progress of the therapy of strengthening spleen to regulate intestinal microecology，and provides a reference for further research on clinical prevention and treatment of colorectal cancer. |
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