To explore the material basis and molecular mechanism of Danggui Liuhuang Decoction in the treatment of patients with arrhythmia by using network pharmacology.Methods:The online database was used to search and screen the targets of Danggui Liuhuang Decoction and Arrhythmia; Cytoscape 7.2 Software was used to construct the traditional Chinese medicine component-target network; STRING Database was used to construct the protein-protein interaction network diagram(PPI) of Danggui Liuhuang Decoction in the treatment of arrhythmia，and find the core targets through topological analysis.Finally，biological pathways and enrichment analysis were performed on drug-disease intersection targets.Results:A total of 135 active ingredients，2714 component targets of Danggui Liuhuang Decoction; 400 targets of arrhythmia disease; and 153 targets of drug components and disease were collected; the topological analysis was carried out by 2 times of the average degree(14.78) to obtain 4 key core targets:NR3C1，NOS3，ESR1，PTGS2; GO biological process and KEGG enrichment analysis showed that treatment of arrhythmia in this way mainly involved 375 biological processes and 34 KEGG pathways.The biological processes mainly involved cell plasma membrane，plasma membrane part，ion binding，intracellular signal cascade，response to organic matter，regulation of cell proliferation and other biological processes; its KEGG pathway was most likely to interact through neuroactive ligand-receptor interactions，followed by calcium signaling pathway and an adrenaline signaling pathway of cardiomyocytes.Conclusion:Danggui Liuhuang Decoction has the characteristics of multiple components，multiple targets and multiple pathways in the treatment of patients with arrhythmia.Its mechanism is relatively complex，and the therapeutic effect may be achieved mainly through the interaction of nerve active ligand-receptor.