| 引用本文:李飞鹤1，裴妙荣2，苏静杰1，陈强1，赵宇杰1.中药破壁饮片与传统饮片对比研究[J].世界中医药,2021,(08):. |
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| 中药破壁饮片与传统饮片对比研究 |
| Comparative Study on Traditional Chinese Medicine's Cell-broken and Traditional Decoction Pieces |
| 投稿时间：2020-02-28 |
| DOI：10.3969/j.issn.1673-7202.2021.08.006 |
| 中文关键词: 破壁饮片 传统饮片 水分 浸出物 含量 指纹图谱 稳定性 |
| English Keywords:Cell-broken decoction pieces Traditional decoction pieces Content of water Extracts Dissolution rate Fingerprints Stability |
| 基金项目:山西省中药现代化关键技术研究振东专项（2014ZD0403）；2016年山西省重点研发计划项目（201603D3111005）——党参种质资源与规范化生产技术研究 |
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| 中文摘要: |
| 目的：采用传统饮片煎煮服用和破壁饮片冲泡服用的模式，从水分、浸出物、有效成分溶出率、指纹图谱和稳定性方面进行对比研究，为破壁饮片临床应用提供参考依据。方法：选取5种传统中药饮片（天麻、当归、罗汉果、党参、三七）与相应破壁饮片按照药典方法进行水分、浸出物、有效成分溶出率、指纹图谱及破壁饮片稳定性研究，在各自最优溶出方法下比较各主要成分的溶出差异。结果：传统饮片的水分含量均大于破壁饮片；浸出物含量基本一致；壁破饮片的溶出量为传统饮片的55%～200%；指纹图谱结果显示溶出成分未见明显差异；12个月的常规稳定性实验表明除当归中阿魏酸的含量不稳定以外，其他基本稳定。结论：中药破壁饮片在水分含量上有各自新的限度；破壁不影响饮片浸出物含量；破壁饮片冲泡的有效成分溶出量基本低于饮片煎煮溶出量；破壁不会改变原饮片物质组成；稳定性除含特殊成分的饮片外，12个月内基本稳定，从服用便捷全草入药综合考虑仍有较大优势。 |
| English Summary: |
| To compare the content of water，extract，the dissolution rate of effective components，finger print，and stability in the boiling mode of traditional decoction pieces and infusing mode of cell-broken decoction pieces through the reasonable experimental design，in order to provide reference for clinical application of cell-broken decoction pieces.Methods:A total of 5 kinds of traditional Chinese medicine decoction pieces(Rhizoma Gastrodiae，Radix Angelicae Sinensis，Fructus Momordicae，Radix Codonopsis，Radix Notoginseng)and corresponding cell-broken pieces were selected to determine the content of water，extract，dissolution rate of effective components，finger print，and their stability according to the Pharmacopoeia method.The dissolution difference of components was compared under each own optimal process of dissolving.Results:The water content of each traditional decoction piece was higher than that of the cell-broken decoction piece; the extract content was basically the same; the dissolution of the cell-broken decoction pieces was was 55%～200% of that of traditional pieces.The finger print showed no significant difference between components dissolving out.The routine stability test for 12 months showed that except for the content of ferulic acid in Radix Angelicae Sinensis，other contents were basically stable.Conclusion:The water content of Chinese medicine cell-broken decoction pieces has its own new limit; the content of the extract of the two is basically the same; the dissolution of the effective components in cell-broken pieces is basically lower than that in the boiling pieces; the stability is basically stable within 12 months except for pieces with special components.It still has a great advantage to choose cell-broken pieces from the perspective of taking whole herb as medicine and convenience. |
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