| 引用本文:程新1，胡江平1，罗方2，于国俊3.针刺联合苓桂术甘汤对维持性血液透析患者口渴的影响[J].世界中医药,2021,(09):. |
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| 针刺联合苓桂术甘汤对维持性血液透析患者口渴的影响 |
| Study on the Effects of Acupuncture Combined with Linggui Zhugan Decoction on Thirst of Maintenance Hemodialysis Patients |
| 投稿时间：2019-04-11 |
| DOI：10.3969/j.issn.1673-7202.2021.09.023 |
| 中文关键词: 维持性血液透析 口渴 针刺 苓桂术甘汤 神经肽 唾液分泌功能 唾液生化功能 疗效 |
| English Keywords:Maintenance hemodialysis Thirst Acupuncture Linggui Zhugan Decoction Neuropeptide Salivary secretory function Salivary biochemical function Curative effects |
| 基金项目:河南省科技攻关项目（142102310166）；河南省中医管理局学科带头人专项课题（2015ZY03011）；郑州市科技攻关项目（20140519） |
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| 中文摘要: |
| 目的：探究针刺联合苓桂术甘汤对维持性血液透析（Maintenance Hemodialysis，MHD）患者口渴的影响。方法：选取2017年1月至2018年1月郑州市中医院收治的MHD口渴患者106例作为研究对象，按照随机数字表法随机法分为对照组和观察组，每组53例。对照组采用常规西医治疗，观察组在对照组基础上加用针刺联合苓桂术甘汤治疗，均治疗4周。观察2组治疗前后血液学、唾液生化、分泌功能、神经肽、相关评分、刺激唾液量及疗效变化。结果：1)治疗后2组尿素氮、血钙、血磷、甲状旁腺激素、尿素下降率、尿素清除指数、标准化蛋白分解率比较差异无统计学意义（P>0.05）。2)治疗后2组酸碱度（pH）、唾液流率指数、Na+/K+、神经降压素(Neurotensin，NT)、刺激唾液量比值较治疗前均升高，Na+、K+、瘦素（Leptin）、血清神经肽Y（NeuropeptideY，NPY）、口渴强度评分、口腔干燥评分、口渴视觉模拟评分（VAS评分）较治疗前下降，差异有统计学意义（P<0.05），且观察组低于对照组，差异有统计学意义（P<0.05）。3)治疗后观察组临床痊愈率、临床有效率均显著高于对照组，差异有统计学意义（P<0.05）。结论：针刺联合苓桂术甘汤能改善MHD患者唾液分泌功能，提高神经肽，从而改善口渴。 |
| English Summary: |
| To explore the effects of acupuncture combined with Linggui Zhugan Decoction on patients with thirst of maintenance hemodialysis(MHD).Methods:A total of 106 patients admitted to Zhengzhou Traditional Chinese Medicine Hospital with MHD thirst were selected as the research objects and according to random number table method, they were divided into a control group(n=53)and an observation group(n=53).The control group was treated with Western medicine，and the observation group was treated with acupuncture combined with Linggui Zhugan Decoction on the basis of the control group.Both groups were treated for 4 weeks.The changes of hematology，saliva biochemistry，secretory function，neuropeptide，related score，stimulated saliva volume and curative effect were observed in the 2 groups before and after treatment.Results:1)There was no significant difference in urea nitrogen，serum calcium，serum phosphorus，parathyroid hormone，urea decline rate，urea clearance index and standardized protein decomposition rate between the 2 groups after treatment(P>0.05).2)After treatment，the pH，salivary flow index，Na+/K+，neurotensin(NT)and the ratio of stimulated saliva volume in the 2 groups were higher than those before treatment，while Na+，K+，leptin，serum neuropeptide Y(NPY)，thirst intensity score，oral dryness score and thirst visual analogue score(VAS score)in the observation group were lower than those before treatment(P＜0.05).The observation group was lower than the control group(P＜0.05).3)After treatment，the clinical curative rate and total effective rate in the observation group were significantly higher than those in the control group(P<0.05).Conclusion:Acupuncture combined with Linggui Zhugan Decoction can improve saliva secretion function，increase neuropeptide and improve thirst in patients with MHD. |
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