Behcet's disease is a chronic systemic inflammatory disease with vasculitis as the basic pathological change.The disease can affect multiple systems with complex conditions and is very easy to relapse.Professor ZHOU Caiyun advocates integrated Chinese and Western medicine for Behcet's disease.She proposes treatment based on stage differentiation and considers that the essential pathological mechanism is not only dampness-heat toxin amassment but also collaterals injury caused by heat toxin.In acute active phase，the key pathogenesis is dampness heat and pathogenic toxin accumulated in interior and heat-toxicity hurting collateral.The main treatment should be clearing heat and removing toxicity，cooling blood and protecting collaterals，assisted by promoting dieresis.In intermission，the main pathological mechanism is deficiency of spleen qi，remnant dampness-heat toxin，and damaged collaterals，which can be treated by replenishing qi and invigorating spleen，with the main treatment at acute phase as its assistance.