To explore the mechanism of Sini powder in the treatment of functional dyspepsia based on network pharmacology and molecular docking method.Methods:The effective components and corresponding target proteins of Sini Powder were screened by TCMSP，and the target of functional dyspepsia were screened by the GeenCards and OMIM data base.R software was used to obtain the common targets of drugs and diseases，and the “component-target-disease”network diagram was constructed by Cytoscape3.7.2 software.The STRING datebase was used to draw the protein interaction(PPI）network，and the DAVID was used to perform GO function and KEGG pathway enrichment analysis on effective targets.AutodockTools1.5.6 was used for docking verification of core targets and core components.Results:The result showed that 144 components were screened and 233 effective targets were screened.The 152 common targets were obtained.The PPI network found that AKT1，IL-6，MARK，JUN，STAT3，etc.may be the key targets for Sini Powder in treatment of functional dyspepsia.The GO function analysis found 795 items.The KEGG parhway analysis found 127 items，including enriched pathways with a large number of genes PI3K-Akt signaling pathway，MAPK signaling pathway，TNF signaling pathway and other pathways.The molecular docking shows that the core target and the core components have strong binding activity.Conclusion:The active components in Sini Powder mainly regulate multiple signaling pathways through targets such as AKT1，IL-6，MARK，JUN and STAT3，thus playing a role in the treatment of functional dyspepsia.