| 引用本文:焦存，芦现杰，尹俊艳，张梅红，谷万里.坤泰胶囊治疗卵巢早衰的Meta分析[J].世界中医药,2021,(10):. |
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| 坤泰胶囊治疗卵巢早衰的Meta分析 |
| Systematic Evaluation of Kuntai Capsule for the Treatment of Premature Ovarian Failure |
| 投稿时间：2020-02-25 |
| DOI：10.3969/j.issn.1673-7202.2021.10.010 |
| 中文关键词: 卵巢早衰 早发性卵巢功能不全 坤泰胶囊 激素替代疗法 随机对照试验 系统评价 Meta分析 循证医学 |
| English Keywords:Premature ovarian failure Premature ovarian insufficiency Kuntai Capsule Hormone replacement treatment Randomized controlled trial Systematic evaluation Meta-analysis Evidence-based medicine |
| 基金项目:国家自然科学基金项目（82004402）;山东省中医药科技发展计划项目（2019-0893） |
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| 中文摘要: |
| 目的：系统评价坤泰胶囊治疗卵巢早衰(POF)的有效性和安全性。方法：检索Cochrane图书馆、PubMed、Medline、中国期刊全文数据库、万方医学数据库、中文科技期刊数据库和SinoMed数据库，检索时限为建库至2019年12月，纳入坤泰胶囊治疗POF的随机对照试验（RCTs），对纳入文献进行质量评价，并采用RevMan 5.3软件进行数据分析。结果：共纳入8项RCTs，包括659例患者。Meta分析结果显示，观察组（坤泰胶囊治疗）与对照组（激素治疗）比较，在总有效率，血清卵泡生成激素（FSH）、黄体生成激素（LH）、雌激素（E2)水平改善方面，差异无统计学意义（P>0.05）；观察组不良反应发生率低于对照组（RR=0.25，95%Cl为0.15~0.42，P<0.000 01）。结论：坤泰胶囊治疗POF的临床疗效与激素治疗相当，安全性优于激素治疗。 |
| English Summary: |
| To evaluate the efficacy and safety of Kuntai Capsule for treating premature ovarian failure(POF).Methods:Databases such as Cochrane library，PubMed，Medline，CNKI，VIP，WanFang，and SinoMed were searched for randomized controlled trials(RCT)from inception of the databases to December 2019.The methodological quality was assessed among the included RCTs.The treatment of POF by Kuntai Capsule or hormone was systematically evaluated by RevMan 5.3 software.Results:A total of 8 RCTs with 659 patients were included.Meta-analysis results showed that the total clinical efficacy，serum FSH level，LH level，and E2 level improvement were not statistically significant between Kuntai capsule group and hormone group(P>0.05).The incidence of adverse reactions was significantly lower in Kuntai Capsule groups compared to hormone groups(RR=0.25，95%CI:0.15 to 0.42，P<0.000 01).Conclusion:The clinical efficacy of Kuntai Capsule in the treatment of POF is comparable to that of hormone therapy，and its safety is superior to that of hormone therapy.However，due to the limited quality and quantity of included studies，more high-quality，large-sample and multi-central RCTs are needed to confirm the above conclusion. |
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