There are comprehensive records of Renzhong in Great Compendium of Acupuncture and Moxibustion than modern clinical.And the acupoint position，operation of traditional Chinese medicine，meridian nature and clinical application were discussed by reviewing the literature records of Renzhong(DU26)in Great Compendium of Acupuncture and Moxibustion.Based on the character of meridians and specific acupoint property，the treatments involve diseases of the heart and brain systems，backache，facial features and oral cavity，rickets，edema，diabetes,and so on.The writer summarize the clinical application to the aspect of regulation of the mind，meridian therapy，specific acupoint property.However modern clinical applications focus on the location and the theory that the acupoint belong to DU Meridian.Less attention is paid to the acupoint's nature of its intersection with the Yangming Meridian，so we can't make the most of it in the edema and diabetes.This paper explains the acupoint's the clinical application of specific diseases.The conclusion of DU26's clinical rules can exactly apply the acupoint and expanding the applied range，which can provide new ideas.