To explore the effects of Tongxinluo Capsules on patients after coronary interventional therapy.Methods:A total of 84 patients with coronary heart disease and angina pectoris admitted to Fuyang Second People's Hospital from January 2018 to December 2019 were selected as the research objects and were randomly divided into a control group and an observation group，with 42 cases in each group.All patients underwent interventional therapy.The control group was treated with low-molecular-weight heparin sodium injection，clopidogrel bisulfate tablets，and aspirin enteric-coated tablets for the treatment after surgery.The observation group was treated with Tongxinluo Capsules on the base of the control group.2 month was a course of treatment，and both groups have 3 courses of treatment.The clinical efficacy of the 2 groups after treatment，the improvement of angina pectoris，endothelial function and hemorheology indexes before and after treatment of the 2 groups were compared.Results:After treatment，the effective rates of clinical symptom improvement and electrocardiogram improvement in the observation group were 97.62% and 85.71%，respectively，were higher than those in the control group(78.57% and 59.52%)(P<0.01).Compared with before treatment，after treatment，the frequency of angina pectoris in the 2 groups decreased，the observation group was lower than the control group(P<0.01)，the duration of angina pectoris was shortened，and the observation group was shorter than the control group(P<0.01).Compared with those before treatment，after treatment，the FMD of the observation group increased and was greater than that of the control group(P<0.01).Compared with those before treatment，after treatment，the whole blood high/low shear viscosity，red blood cell aggregation index，plasma viscosity，hematocrit decreased of the 2 groups decreased(P<0.05 or P<0.01)，and the observation group was lower than the control group(P<0.05 or P<0.01).Conclusion:Tongxinluo Capsules could significantly improve the symptoms of angina pectoris in patients with coronary heart disease and angina pectoris undergoing interventional therapy，and could improve the endothelial function and blood hypercoagulability of patients after surgery，thereby helping to improve the clinical symptoms of patients and improve the efficacy.