| 引用本文:潘强强1，卢家忠1，张标1，吕新才1，潘登月1，戎成政1，赵德轩2，侯秀洁3.通心络胶囊对冠心病介入治疗手术后患者的疗效[J].世界中医药,2021,(10):. |
|
| 通心络胶囊对冠心病介入治疗手术后患者的疗效 |
| Analysis of the Curative Effects of Tongxinluo Capsules on Patients After Coronary Interventional Therapy |
| 投稿时间：2021-04-13 |
| DOI：10.3969/j.issn.1673-7202.2021.10.014 |
| 中文关键词: 冠心病 心绞痛皮冠状动脉 介入治疗 通心络胶囊 心电图 内皮功能 血流变学 疗效 |
| English Keywords:Coronary heart disease Angina pectoris Percutaneous Coronary Intervention Tongxinluo Capsules Electrocardiogram Endothelial function Hemorheology Efficacy |
| 基金项目:安徽省重点研究与开发计划项目(1508085QH161) |
|
| 摘要点击次数: 284 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的:探究通心络胶囊对冠心病患者经皮冠状动脉介入治疗（PCI）后患者的疗效。方法:选取2018年1月至2019年12月阜阳市第二人民医院收治的冠心病心绞痛患者84例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组42例。所有患者均行PCI,对照组手术后给予低分子肝素钠注射液、硫酸氢氯吡格雷片、阿司匹林肠溶片治疗,观察组在此基础上联合通心络胶囊治疗,2个月为1个疗程,2组均治疗3个疗程。比较2组治疗后的临床疗效,治疗前后的心绞痛改善情况、内皮功能及血流变学指标。结果:治疗后,观察组临床症状改善、心电图改善有效率分别为97.62%、85.71%,均高于对照组的78.57%、59.52%(P<0.05)。与治疗前比较,治疗后,2组心绞痛发作频率降低,观察组低于对照组(P<0.05),心绞痛持续时间缩短,观察组短于对照组(P<0.05)。与治疗前比较,治疗后,观察组血管内皮依赖性舒张功能(FMD)增大,且大于对照组(P<0.05)。与治疗前比较,治疗后,2组全血高/低切黏度、红细胞聚集指数、血浆黏度、红细胞压积均降低(P<0.05),观察组低于对照组(P<0.05)。结论:通心络胶囊可改善行介入治疗的冠心病心绞痛患者心绞痛症状,并可改善患者手术后内皮功能及血液高凝状态,进而有助于改善患者临床症状,提高疗效。 |
| English Summary: |
| To explore the effects of Tongxinluo Capsules on patients after coronary interventional therapy.Methods:A total of 84 patients with coronary heart disease and angina pectoris admitted to Fuyang Second People's Hospital from January 2018 to December 2019 were selected as the research objects and were randomly divided into a control group and an observation group，with 42 cases in each group.All patients underwent interventional therapy.The control group was treated with low-molecular-weight heparin sodium injection，clopidogrel bisulfate tablets，and aspirin enteric-coated tablets for the treatment after surgery.The observation group was treated with Tongxinluo Capsules on the base of the control group.2 month was a course of treatment，and both groups have 3 courses of treatment.The clinical efficacy of the 2 groups after treatment，the improvement of angina pectoris，endothelial function and hemorheology indexes before and after treatment of the 2 groups were compared.Results:After treatment，the effective rates of clinical symptom improvement and electrocardiogram improvement in the observation group were 97.62% and 85.71%，respectively，were higher than those in the control group(78.57% and 59.52%)(P<0.01).Compared with before treatment，after treatment，the frequency of angina pectoris in the 2 groups decreased，the observation group was lower than the control group(P<0.01)，the duration of angina pectoris was shortened，and the observation group was shorter than the control group(P<0.01).Compared with those before treatment，after treatment，the FMD of the observation group increased and was greater than that of the control group(P<0.01).Compared with those before treatment，after treatment，the whole blood high/low shear viscosity，red blood cell aggregation index，plasma viscosity，hematocrit decreased of the 2 groups decreased(P<0.05 or P<0.01)，and the observation group was lower than the control group(P<0.05 or P<0.01).Conclusion:Tongxinluo Capsules could significantly improve the symptoms of angina pectoris in patients with coronary heart disease and angina pectoris undergoing interventional therapy，and could improve the endothelial function and blood hypercoagulability of patients after surgery，thereby helping to improve the clinical symptoms of patients and improve the efficacy. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
