To sort out and analyze the prescriptions for the treatment of depression disease in the Dictionary of Traditional Chinese Medicine Prescriptions，and to explore the medication rules of treating depression disease in traditional Chinese medicine(TCM).Methods:The prescriptions for treating depression disease in the Dictionary of Traditional Chinese Medicine Prescriptions were collected，the “Cloud Platform of Ancient and Modern Medical Case(V1.6.3)” was used to conduct data mining on the prescriptions for treating depression disease from the perspectives of single drug frequency，drug pair correlation，efficacy，nature and flavor，clustering prescription，and clinical syndrome differentiation prescription，and to analyze the medication law.Results:A total of 207 prescriptions were selected，including 285 kinds of drugs，including 24 drugs with frequency ≥22 times.The top four prescriptions were Poria，Radix Glycyrrhizae，Radix Ginseng，Radix Angelicae Sinensis.The top 3 TCM pairs were Poria，Radix Glycyrrhizae，Radix Ginseng，Poria，Radix Polygalae，Radix Ginseng.Among the drugs for treating depression，the drug with the calming the heart effect is the first，followed by the drug with calming the mind，enriching the mind，clearing heat and detoxifying，and purifying the bowels; Most of the four qi of the medicine are warm and flat，while the five flavors of the medicine are sweet，followed by pungent; 3 new prescriptions were obtained by clustering the top 24 Chinese medicines.Conclusion:In the treatment of depression disease in TCM，the main method is to calm the heart and calm the mind，and to enrich the mind and benefit wisdom，supplemented by regulating qi，nourishing the deficiency，clearing heat and detoxifying，and moistening the bowels.