| 引用本文:王亚芬1,2，旷湘楠1,2，尹玉洁3,4,5，韩宁馨6，郝苑洁6，魏亚茹1,2，王晓琪1,2，贾振华1,2,3,4,5.缺氧对阻塞性睡眠呼吸暂停综合征与动脉粥样硬化的影响[J].世界中医药,2021,(11):. |
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| 缺氧对阻塞性睡眠呼吸暂停综合征与动脉粥样硬化的影响 |
| Research Progress on the Mechanism of Hypoxia in Atherosclerosis Associated with Obstructive Sleep Apnea Syndrome |
| 投稿时间：2021-04-20 |
| DOI：10.3969/j.issn.1673-7202.2021.11.002 |
| 中文关键词: 间歇性缺氧 阻塞性睡眠呼吸暂停综合征 动脉粥样硬化 炎症 内皮功能障碍 氧化应激 代谢失调 血小板聚集和活化 交感神经活动 |
| English Keywords:Intermittent hypoxia Obstructive sleep apnea syndrome Atherosclerosis Inflammation Endothelial dysfunction Oxidative stress Metabolic dysregulation Platelet Aggregation and activation Sympathetic nerve activity |
| 基金项目:国家重点研发计划中医药现代化研究中医药专项(2017YFC1700500) |
| 作者 | 单位 | | 王亚芬1,2，旷湘楠1,2，尹玉洁3,4,5，韩宁馨6，郝苑洁6，魏亚茹1,2，王晓琪1,2，贾振华1,2,3,4,5 | 1 河北中医学院研究生学院，石家庄，050090； 2 河北以岭医院，石家庄，050091； 3 络病研究与创新中药国家重点实验室，国家中医药管理局重点研究室，石家庄，050035； 4 国家中医药管理局重点研究室心脑血管络病，石家庄，050035； 5 河北省中西医结合医药研究院，石家庄，050035； 6 河北医科大学研究生院，石家庄，050017 |
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| 中文摘要: |
| 阻塞性睡眠呼吸暂停综合征（OSAS）是一种常见的以睡眠时上气道反复塌陷为特征的慢性睡眠呼吸疾病，与高脂血症、动脉粥样硬化和心血管风险相关。近年来，已有研究证实OSAS是动脉粥样硬化（AS）形成的独立危险因素，会加速AS的发生和发展。目前有理论提出动脉粥样硬化发生的关键因素之一是动脉壁氧供需不平衡，而OSAS的典型特征是慢性间歇性缺氧（CIH），所以推测CIH可能是OSAS加速AS形成的中间机制，然而其具体机制尚未完全明确，因此现就其可能的机制进行综述，以期为临床治疗和研究提供启示。 |
| English Summary: |
| Obstructive sleep apnea syndrome(OSAS) is a common chronic sleep breathing disorder characterized by repeated upper airway collapse during sleep,and is associated with hyperlipidemia,atherosclerosis,and cardiovascular risks.In recent years,studies have confirmed that OSAS is an independent risk factor for the formation of atherosclerosis(AS) and will accelerate the occurrence and development of AS.At present,there are theories that one of the key factors in the occurrence of atherosclerosis is the imbalance between the supply and demand of oxygen in the arterial wall,and the typical feature of OSAS is chronic intermittent hypoxia(CIH),so it is speculated that CIH may be an intermediate mechanism for OSAS to accelerate the formation of AS.However,the specific mechanism has not yet been fully clarified,so this paper summarizes its possible mechanism as follows,in order to provide enlightenment for clinical treatment and research. |
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