To observe the effect of “Congpi Lunzhi Formula” on vasoactive factors in ITP mice，and to explore the hemostatic effect mechanism of “Congpi Lunzhi Formula”.Methods:The ITP mice immune model was established by means of passive immunization.Prednisone，Guipi Decoction，Jianpi Yiqi Decoction，Jianpi Yiqi Shexue Formula were used as intervention drugs，and serum ET-1，NO，NOS3，TXA2，PGI2，vWF，VCAM-1 of model mice were detected by ELISA and TM levels were detected by ELISA.Results:1)Increasing efficacy of platelet：On the 15th day after APS injection(the 8th day of administration)，the PLT count in the peripheral blood of the model control group was still significantly lower than that of the normal control group，while the peripheral blood PLT of the mice in the model control group was lower than the normal control group.However，the peripheral blood PLT of mice in each administration group had no statistical difference compared with the normal control group，and was significantly higher than the model control group.2)Hemostatic effect：After injection of APS，mice in each group have different degrees of bleeding tendency.On the 6th and 8th day of drug intervention，the bleeding level of each experimental group was significantly lower than that of the model control group.3)Vascular procoagulant activity factors：the levels of VCAM-1 in each experimental group were significantly lower than those in the normal control group; the levels of VCAM-1 in the Jianpi Yiqi group and the Guipi Decoction group were significantly higher than those in the model control group and the prednisone group.The level of VCAM-1 in the Jianpi Yiqi Shexue group was significantly higher than that in the prednisone group.4)Vascular anticoagulant activity factors：the TM levels of each experimental group were significantly lower than those of the normal control group，and the TM levels of Jianpi Yiqi Shexue group were significantly lower than the model control group.Conclusion:Treatment from spleen could improve PLT count of ITP model mice，degrade the bleeding scale.Moreover，it can upregulate VCAM-1，downregulate TM，keep the dynamic balance of coagulant and anticoagulant factors.