| 引用本文:傅馨莹1，孙正骥1，张伟2.基于“内皮损伤学说”探讨动脉粥样硬化的中医药防治策略[J].世界中医药,2021,(11):. |
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| 基于“内皮损伤学说”探讨动脉粥样硬化的中医药防治策略 |
| Discussion on Prevention and Treatment Strategy of Atherosclerosis with Traditional Chinese Medicine Based on “the Theory of Endothelial Injury” |
| 投稿时间：2020-04-24 |
| DOI：10.3969/j.issn.1673-7202.2021.11.024 |
| 中文关键词: 血管内皮功能障碍 血管内皮损伤 动脉粥样硬化 Genecards数据库 中医药 炎症反应 氧化应激 内皮细胞 |
| English Keywords:Vascular endothelial dysfunction Vascular endothelial injury Atherosclerosis Genecards database Traditional Chinese medicine Inflammatory response Oxidative stress Vascular endothelial cells |
| 基金项目:国家自然科学基金项目（81774032）；湖南省自然科学杰出青年基金项目（2020JJ2024）；湖南省自然科学青年基金项目（2018JJ3391）；湖南省教育厅科学研究重点项目（19A374）；湖南中医药大学研究生培养质量工程专项（2020CX62） |
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| 中文摘要: |
| 基于“动脉粥样硬化内皮损伤学说”，探讨在动脉粥样硬化（AS）疾病发生发展过程中，血管内皮功能障碍与血管内皮损伤的联系及区别。阐述血管内皮功能障碍与血管内皮损伤的概念，从血管内皮细胞分泌的一氧化氮/内皮素（NO/ET）稳态，诱发的炎症反应及氧化应激的角度和激活的VECF、MAKP、JAK/STAT、PI3K-AKT通路出发，探讨动脉粥样硬化疾病进程中二者的联系与区别。通过检索Genecards数据库，筛选血管内皮功能障碍、血管内皮损伤及AS的相关靶点，从分子角度进一步论证。阐明中药对血管内皮功能障碍及血管内皮损伤的保护及修复作用。 |
| English Summary: |
| Based on the theory of atherosclerotic endothelial injury，this paper discusses the relationship and difference between vascular endothelial dysfunction and vascular endothelial injury in the course of occurrence and development of atherosclerotic diseases.This paper firstly describes the concepts of vascular endothelial dysfunction and vascular endothelial injury，and explores the relationship and difference between the two in the process of atherosclerotic disease from the point of view of NO/ET homeostasis secreted by vascular endothelial cells，inflammatory response and oxidative stress induced by vascular endothelial cells and activated VECF，MAKP，JAK/STAT，PI3K-AKT signaling pathway.Then the Genecards database were searched to screen the related targets of vascular endothelial dysfunction，vascular endothelial injury and AS，which were further demonstrated from the molecular point of view.Finally，the protective and repair effects of traditional Chinese medicine on vascular endothelial dysfunction and vascular endothelial injury were described. |
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