| 引用本文:唐开强，穆晓红，叶超，刘向春，亓建，康晓乐，王悦，许卢春，王建军.乳香-没药治疗类风湿性关节炎的网络药理学和生物信息学分析[J].世界中医药,2021,(12):. |
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| 乳香-没药治疗类风湿性关节炎的网络药理学和生物信息学分析 |
| Analysis of Olibanum-Myrrha in the Treatment of Rheumatoid Arthritis Based on Network Pharmacology and Bioinformatics |
| 投稿时间：2020-09-03 |
| DOI：10.3969/j.issn.1673-7202.2021.12.001 |
| 中文关键词: 乳香 没药 类风湿性关节炎 网络药理学 生物信息学 作用机制 作用靶点 信号通路 |
| English Keywords:Olibanum Myrrha Rheumatoid arthritis Network pharmacology Bioinformatics Mechanism of action Target of action Signalling pathways |
| 基金项目:北京市自然科学基金项目(7182102) |
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| 中文摘要: |
| 目的:研究乳香-没药药对治疗类风湿性关节炎(Rheumatoid Arthritis，RA)的作用机制。方法:依托GEO、GeneCards、OMIM数据库挖掘RA相关基因并进行合并。通过中药系统药理学数据库与分析平台（TCMSP）检索乳香-没药的有效化学成分和相关靶点，使用Cytoscape 3.8.0软件绘制“药物-成分-靶标-信号途径”的可视化网络。运用STRING数据库构建化合物靶点蛋白质-蛋白质相互作用（PPI）网络。运用R软件进行基因本体（GO）富集分析和京都基因和基因组百科全书（KEGG）通路富集分析。结果:GEO、GeneCards、OMIM数据库筛选出类风湿性关节炎相关基因4 655个，共筛选出乳香-没药药对主要活性成分46个，对应靶点90个。获得乳香-没药治疗类风湿性关节炎的靶点60个，核心靶点6个。此外，KEGG通路富集结果主要包括流体剪切应力与动脉粥样硬化、AGE-RAGE信号通路、白细胞介素-17信号通路。结论:乳香-没药药对可通过多靶点、多通路来治疗类风湿性关节炎。 |
| English Summary: |
| To explore the mechanism of Olibanum-Myrrha medicine in the treatment of rheumatoid arthritis.Methods:Relying on GEO, GeneCards, and OMIM databases to mine and merge RA-related genes.The effective chemical components and related targets of Boswellia-Myrrha were searched through TCMSP, and the visual network of “drug-component-target-signal pathway” was drawn using Cytoscape 3.8.0 software.STRING database was used to construct a compound target protein interaction network.R software was used for GO function and KEGG pathway enrichment analysis.Results:The GEO, GeneCards, and OMIM databases were used to screen out 4,655 rheumatoid arthritis-related genes, and a total of 46 main active ingredients of Olibanum-Myrrha pair were screened, corresponding to 90 targets.A total of 60 frankincense-myrrha treatment targets for rheumatoid arthritis and 6 core targets were obtained.In addition, the enrichment results of KEGG pathway mainly include fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway, and interleukin-17 signaling pathway.Conclusion:Olibanum-Myrrha can treat rheumatoid arthritis through multiple targets and multiple pathways. |
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