| 引用本文:冯汝丽1,2，崔晓云3，邓宇童1,3，曲信彦1,2，毛天诗1,2，谢龙1,2，李星1,3，刘静3，高群2，林谦2.口服中药治疗不稳定型心绞痛患者远期预后及疗效的Meta分析[J].世界中医药,2021,(12):. |
|
| 口服中药治疗不稳定型心绞痛患者远期预后及疗效的Meta分析 |
| Long-Term Prognosis and Efficacy of Oral Chinese Medicine in the Treatment of Unstable Angina Pectoris:A Meta-analysis |
| 投稿时间：2020-04-17 |
| DOI：10.3969/j.issn.1673-7202.2021.12.001 |
| 中文关键词: 不稳定型心绞痛 治疗 口服中药 随机对照试验 主要不良心血管事件 疗效 安全性 Meta分析 |
| English Keywords:Unstable angina pectoris Treatment Oral Chinese medicine Randomized controlled trials Major adverse cardiovascular events Efficacy Safety Meta-analysis |
| 基金项目:北京市科委首都临床诊疗技术研究及示范应用项目（Z191100006619071） |
|
| 摘要点击次数: 674 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：运用Meta分析的方法评价口服中药治疗不稳定型心绞痛的远期预后及疗效。方法：应用计算机检索中国期刊全文数据库、万方医学数据库、中文科技期刊数据库，PubMed，EMBASE，Cochrane lib，Google及Web of Science数据库，检索时间为2000年1月1日至2020年1月1日。研究员筛选文献、提取资料、评价偏倚风险并交叉核对后，采用Review Manager 5.3及STATA SE 12软件进行Meta分析。结果：最终纳入符合标准的随机对照试验28篇，3 025例患者。Meta分析结果显示口服中药能够改善不稳定型心绞痛远期预后，减少主要不良心血管事件（MACE）发生，并且在心电图（OR=2.38，95%CI为1.84~3.09，P<0.000 01）、心绞痛发作次数（SMD=-0.87,95%CI为-1.14~-0.60，P<0.000 01）、心绞痛发作时间（SMD=-0.62,95%CI为-0.88~-0.36，P<0.000 01）、硝酸甘油用量（SMD=-1.72，95%CI为-2.33~-1.12，P<0.000 01）以及硝酸甘油停减率（OR=2.80，95%CI为1.76~4.44，P<0.000 1）方面疗效优于单用常规治疗，口服中药未增加不良反应（OR=1.14，95%CI为0.65~1.99，P=0.64），疗效及安全性较好。结论：口服中药治疗不稳定型心绞痛可改善患者远期预后。 |
| English Summary: |
| To evaluate long-term prognosis and efficacy of oral Chinese medicine in the treatment of unstable angina pectoris.Methods:Electronic databases included CNKI，VIP，Wanfang，PubMed，EMBASE，Cochrane lib，Google and Web of Science were searched(published date from January 1，2000 to February 1，2020).After reviewers screened out the literature，extracted information，evaluated risk of bias and cross checked，Review Manager 5.3 and STATA SE 12 were used for the meta-analysis.Results:A total of 28 studies involving 3025 patients were included.The results of meta-analysis showed that oral Chinese medicine could improve the long-term prognosis of unstable angina pectoris，and reduce the occurrence of major adverse cardiovascular events(MACE).In terms of electrocardiogram ［OR=2.38，95%CI(1.84 to 3.09)，P<0.000 01］，number of angina attacks ［SMD=-0.87，95%CI(-1.14 to -0.60)，P<0.000 01］，duration of angina ［SMD=-0.62，95%CI(-0.88 to -0.36)，P<0.000 01］，consumption of nitroglycerin ［SMD=-1.72，95%CI(-2.33 to -1.12)，P<0.000 01］，rate of nitroglycerin reduction ［OR=2.80，95%CI(1.76 to 4.44)，P<0.000 1］，oral Chinese medicine was better than conventional treatment alone.No additional adverse reactions happened ［OR=1.14，95%CI(0.65 to 1.99)，P=0.64］，indicating better efficacy and more safety.Conclusion:Using oral Chinese medicine for unstable angina pectoris can improve the long-term prognosis yet more research with higher-quality and is still needed to further prove it in the future. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
